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RecruitingNCT05999188CLASSICUpdated Jul 12, 2024

Clinical Characteristics and Prognosis of Aortic Dissection in China (CLASSIC)

An observational study in Aortic Dissection, sponsored by First Affiliated Hospital Xi'an Jiaotong University. Recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2024-07-12.

Sponsored by First Affiliated Hospital Xi'an Jiaotong University · Observational

From the registry’s dates

  • Started Oct 2023; still recruiting 2 years 11 months later.
Study type
Observational
Model
Cohort
Time perspective
Other
Enrollment
100
Ages
18 Years to 80 Years
Sex
All
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Study summary

This study will construct a retrospective-prospective long-term follow-up cohort and management system for aortic dissection through a multicentre collaborative network. This study aims to investigate the disease characteristics, progression patterns, clinical features, natural course and factors affecting the disease course and prognosis of patients with aortic dissection by retrospectively collecting data and prospectively enrolling patients.

Read the detailed description

This study aims to construct a retrospective-prospective long-term follow-up cohort and management system for aortic dissection through a multicentre collaborative network. The duration of the study will be divided into retrospective and prospective components. The retrospective study will collect cases of aortic dissection of different aetiologies from 2003-2022; the prospective study is expected to collect cases of aortic dissection from 2022-2030. The study is expected to assess the disease characteristics, progression patterns, clinical features, natural course and long-term prognosis of aortic coarctation.

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Conditions studied

  • Aortic Dissection

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Keywords

  • aortic dissection
  • clinical characteristics
  • prognosis
03

In context

Aortic Dissection

386 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.

This study's planned enrollment of 100 is below the median of 183 across 180 observational studies indexed under Aortic Dissection.

Browse Aortic Dissection studies →

Lead sponsor

First Affiliated Hospital Xi'an Jiaotong University is the lead sponsor of 306 studies on the registry; 86 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients who are aged 18-80 years and diagnosed with aortic dissection at any of the centre can be enrolled.

Inclusion criteria

  • Age 18-80 years;
  • Meet diagnostic criteria for aortic dissection.

Exclusion criteria

Exclusion Criteria:

  • Age \<18 years or >80 years;
  • Women who are pregnant and breastfeeding;
  • Patients and their families refuse or are unable to sign the informed consent form.
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Study design

Observational model
Cohort
Time perspective
Other
Enrollment
100 participants (estimated)
Target follow-up
5 Years
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • Aortic dissection group

    Patients diagnosed with aortic dissection at any of the centres and regularly consulted and followed up.

    Other: Observational

Interventions

  • OtherObservational

    No interventions will be given to patients.

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What researchers measure

Primary outcomes

  1. Change of post-operative survival rate

    Post-operative survival rate of patients after aortic dissection surgery in 3, 6, 9 month and 1, 2, 3, 4, 5 year. The survival situation will be assessed by telephone follow-up.

    Time frame: 3, 6, 9 month and 1, 2, 3, 4, 5 year after the surgery.

Secondary outcomes

  1. Change of the incidence of MACCE

    Major adverse cardio-cerebrovascular events included myocardial infarction, stroke, revascularization and all-cause death. The occurrence of MACCE will be assessed by telephone follow-up and medical records.

    Time frame: 3, 6, 9 month and 1, 2, 3, 4, 5 year after the surgery.

  2. Incidence of any complications

    Any complications diagnosed by doctors. The occurrence of complications will be decided by medical records.

    Time frame: 5 years after the surgery.

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Study locations

1 of 1 sites recruiting
  • First Affiliated Hospital of Xian Jiantong University
    Xi'an, Shaanxi 710061, China
    Recruiting
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 12, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT05999188
Lead sponsor
First Affiliated Hospital Xi'an Jiaotong University
Collaborators
521 Hospital of NORINCO Group, Shaanxi Provincial People's Hospital, Xiangyang Central Hospital, Henan Provincial People's Hospital
Responsible party
Sponsor
First posted
Aug 21, 2023
Start date
Oct 30, 2023
Primary completion
Oct 12, 2030 (estimated)
Completion
Dec 12, 2030 (estimated)
Last update
Jul 12, 2024

Study contacts

Guoliang Li
Contact
liguoliang_med@163.com
0086-029-13759982523
Guoliang Li
principal investigator · First Affiliated Hospital Xi'an Jiaotong University
Yang Yan
principal investigator · First Affiliated Hospital Xi'an Jiaotong University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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