RecruitingNCT05955573Updated Mar 19, 2024

Knee Osteoarthritis, Aging and Metabolic Syndrome

An observational study in Knee Osteoarthritis, sponsored by Sohag University. Recruiting at 1 site in Egypt. Open to participants aged 30 Years and older. Per ClinicalTrials.gov, last updated 2024-03-19.

Sponsored by Sohag University · Observational

From the registry’s dates

Primary completion was expected by Jun 2024, 2 years 4 months ago, but the record still lists the study as recruiting.
Started Aug 2023; still recruiting 3 years 1 month later.

Study type: Observational
Model: Case-only
Time perspective: Cross-sectional
Enrollment: 50
Ages: 30 Years and older
Sex: All

Study summary

Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis

Read the detailed description

Place of the study: Sohag university hospital.
Type of study: Cross-Sectional Observational study
Study period: Six months to one year The study will include Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA .

The following details will be obtained:

Demographic data : Age ,Sex ,Marital status ,Occupation ,Residence ,Education level
,Anthropometrical measures which included waist circumference (WC) and blood pressure (BP) will be obtained,History of chronic diseases (eg; Diabetes mellites, Hypertension)
Clinical information: Symptom and its Duration. Plain radiographs of at least one knee [anteroposterior (A/P), lateral} will be taken.
Laboratory findings included fasting blood sugar, serum levels of triglycerides, High-density lipoprotein cholesterol and total cholesterol.

Conditions studied

Knee Osteoarthritis

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Keywords

knee osteoarthritis
Aging
Metabolic Syndrome

In context

Osteoarthritis

4,398 studies on the registry are indexed under Osteoarthritis; 583 are open to participants now.

This study's planned enrollment of 50 is below the median of 100 across 792 observational studies indexed under Osteoarthritis.

Browse Osteoarthritis studies →

Lead sponsor

Sohag University is the lead sponsor of 1,183 studies on the registry; 612 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 30 Years and older
Sexes eligible: All
Accepts healthy volunteers: No
Sampling method: Probability sample

Study population

knee osteoartgritis

Inclusion criteria

Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA and had symptomatic OA of at least 1 knee (index knee), with a Kellgren / Lawrence (K/L) score ≥ 1 in that knee

Exclusion criteria

Exclusion Criteria:

Any patient with a history of trauma to the knee
- Any other form of arthritis (e.g., rheumatoid arthritis, seronegative spondyloarthropathies, gout, pyrophosphate disease, or other crystal arthropathy)

Study design

Observational model: Case-only
Time perspective: Cross-sectional
Enrollment: 50 participants (estimated)
Target follow-up: 1 Month
Patient registry: Yes

Groups and cohorts

knee osteoarthritis
Knee osteoarthritis
Diagnostic Test: xray

Interventions

Diagnostic testxray
radiological description

What researchers measure

Primary outcomes

severity of knee osteoarthritis
Kellgren and Lawrence (K/L) grading system of Knee osteoarthritis. It assigned a grade from 0 to 4, which they correlated to increasing severity of OA, with Grade 0 signifying no presence of OA and Grade 4 signifying severe OA .
Time frame: 8/2023-8/2024

Study locations

1 of 1 sites recruiting

Sohag Faculty of Medicine
Sohag, Egypt
Recruiting

References and documents

Publications

Englund, M. (202+3). Osteoarthritis, part of life or a curable disease? A bird's-eye view. In Journal of Internal Medicine. John Wiley and Sons Inc. https://doi.org/10.1111/joim.13634 Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., Spertus, J. A., & Costa, F. (2005). Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute scientific statement. In Circulation (Vol. 112, Issue 17, pp. 2735-2752). https://doi.org/10.1161/CIRCULATIONAHA.105.169404 KELLGREN, J. H., & LAWRENCE, J. S. (1957). Radiological assessment of osteo-arthrosis. Annals of the Rheumatic Diseases, 16(4), 494-502. https://doi.org/10
Krasnokutsky S, Oshinsky C, Attur M, Ma S, Zhou H, Zheng F, Chen M, Patel J, Samuels J, Pike VC, Regatte R, Bencardino J, Rybak L, Abramson S, Pillinger MH. Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients With Medial Knee Osteoarthritis. Arthritis Rheumatol. 2017 Jun;69(6):1213-1220. doi: 10.1002/art.40069. Epub 2017 Apr 28. PubMed 28217895 ↗

Individual participant data

Plan to share: No

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Mar 19, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT05955573
Lead sponsor: Sohag University
Responsible party: Amany Mohamed Abdelrahman (Physical Medicine, Rheumatology and Rehabilitation Department, Sohag University) — Principal investigator
First posted: Jul 21, 2023
Start date: Aug 20, 2023
Primary completion: Jun 2024 (estimated)
Completion: Aug 2024 (estimated)
Last update: Mar 19, 2024

Study contacts

Amany Mohamed abdelrahman, master

Contact

amanymohamed@med.sohag.edu.eg

01066706352

Hanan Sayed Abo-zaid, MD

Contact

01150532194

Dalia Shaker Elgendy, MD

study chair · Sohag University

Hanan Sayed Abo-zaid, MD

study director · Sohag University

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

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