An interventional study of Gum base containing xylitol and essencial oils and Gum base with no additives in Dental Plaque, Dental Caries and Periodontal Disease, sponsored by University of Toronto. Not yet recruiting. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-14.
Sponsored by University of Toronto · Not applicable, Interventional, and Prevention
This research study is designed to evaluate the chewing gum's ability to modulate the oral microbiome in human participants, in addition to its safety.
The goal of this project is to develop a pre-biotic chewing gum that is designed to promote a healthy oral microbiome. The gum will contain compounds that will: a) be unable to be converted to acids; b) target the cariogenic S. mutans population; c) promote the stability of a healthy environment by modulating plaque pH via base-generating compounds; d) promote tooth remineralization by increasing saliva flow and by addition of calcium phosphate.
1,110 studies on the registry are indexed under Dental Caries; 197 are open to participants now.
This study's planned enrollment of 30 is below the median of 60 across 917 interventional studies indexed under Dental Caries.
Browse Dental Caries studies →University of Toronto is the lead sponsor of 397 studies on the registry; 59 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will be asked to chew 2 pieces of chewing gum containing additives 2 times a day for a four-week period
Dietary Supplement: Gum base containing xylitol and essencial oils
Participants will be asked to chew 2 pieces of pure gum base with no additives chewing gum 2 times a day for the same four-week period.
Dietary Supplement: Gum base with no additives
Participants will be asked to chew 2 pieces of chewing gum containing additives for 10 minutes after eating in the morning, and after one meal in the evening, for a four-week period
Participants will be asked to chew 2 pieces of pure gum base for 10 minutes after eating in the morning, and after one meal in the evening, for a four-week period
Change in target species of the oral microbiome
Total microbiome analyses will be performed at the beginning and end of the study (4 weeks) to assess total cultivable flora, levels of S. mutans, S. salivarius, and P. gingivalis in addition to using qRT-PCR from plaque and saliva samples
Time frame: 28 days
No study locations are listed for this record.
This study is not yet recruiting, as verified in Jul 2023. You cannot join it, but the record below documents what was studied.
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University of Toronto