An Early Phase 1 interventional study of Reat ETM and Hypothetical ETM in Cigarette Smoking, sponsored by Virginia Polytechnic Institute and State University. Completed at 1 site in United States. Open to participants aged 21 Years and older. Per ClinicalTrials.gov, last updated 2026-06-05.
Sponsored by Virginia Polytechnic Institute and State University · Early Phase 1, Interventional, and Basic science
This study will experimentally assess the comparability of in-lab and remote procedures with hypothetical and real ETM purchase outcomes.
In a between-group within-subject repeated measures design, participants will be randomly assigned to one of two procedures (in-lab or remote; between-group) and complete two conditions (real and hypothetical; within-subject), which include six trials assessing increasing cigarette prices.
114 studies on the registry are indexed under Cigarette Smoking; 59 are open to participants now.
This study's enrollment of 87 is below the median of 100 across 101 interventional studies indexed under Cigarette Smoking.
Browse Cigarette Smoking studies →Virginia Polytechnic Institute and State University is the lead sponsor of 124 studies on the registry; 27 are open to participants now.
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Exclusion Criteria:
Exclusive cigarette smokers will be recruited and will experience all study procedures in the laboratory.
Drug: Reat ETM · Drug: Hypothetical ETM
Exclusive cigarette smokers will be recruited and will experience all study procedures remotely.
Drug: Reat ETM · Drug: Hypothetical ETM
Exclusive cigarette smokers will be recruited and will be exposed to the real ETM condition in which tobacco purchases are real and they receive products from one randomly selected trial.
Exclusive cigarette smokers will be recruited and will be exposed to the hypothetical ETM condition in which tobacco purchases are hypothetical and they don't receive any products.
Cigarette demand
Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will remain constant. To obtain dependent measures of demand, participants' purchasing of the price-manipulated commodity in the ETM task will be fit to a modified exponential equation to quantify the relationship between the price of each commodity and purchasing: Q=Q0\*10k(exp(-αQ0C)-1) where Q is purchasing of the commodity, C is the price, Q0 is the derived initial purchasing without cost constraints (demand intensity), k is the span of the function in logarithmic units, and α is the demand elasticity.
Time frame: 1 day
Nicotine/tobacco products substitution
Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will remain constant. To obtain estimates of substitution of price-constant products in the different ETM conditions, the investigators will use ordinary least squares regression to model the relationship of the price-manipulated product to predict total quantity purchased of the price-constant product.
Time frame: 1 day
Plan to share: No — The study team will share de-identified data upon request.
No publications or documents are linked to this record.
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Virginia Polytechnic Institute and State University