An interventional study of Non-Menthol Cigarettes and Tobacco Flavored E-cigarettes in Smoking Prevention and Control, sponsored by Medical University of South Carolina. Recruiting at 1 site in United States. Open to participants aged 21 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-21.
Sponsored by Medical University of South Carolina · Not applicable, Interventional, and Prevention
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Among 30 studies in Smoking by Medical University of South Carolina — 8 open to participants now, 8 under way, none of them phase 3. Smoking · Medical University of South Carolina.
Among the 30 studies in Smoking by Medical University of South Carolina, this one is the 9th largest by planned enrollment of the 29 interventional ones that give a count, is the only one that started in 2023, is one of 23 with no phase, and was the 24th registered.
1,510 studies on the registry are indexed under Smoking; 193 are open to participants now.
Browse Smoking studies →8 of the 30 studies in Smoking by Medical University of South Carolina are open now, in 1 country. Recruiting first, the newest first:
Medical University of South Carolina · Sites in United States
Ages 21+ · Healthy volunteers
Medical University of South Carolina · Sites in United States
Ages 21+ · Healthy volunteers
Medical University of South Carolina · Sites in United States
Ages 21+ · Healthy volunteers
Medical University of South Carolina · Sites in United States
Ages 21+
Medical University of South Carolina · Sites in United States
Ages 21+
By country, each count listing its studies:
Of the 140 Smoking studies recruiting now, 74 (53%) set no upper age limit and 48 (34%) stop at 75 or younger; 3 take children under 18; 65 take healthy volunteers.
This study: 21 Years and older · all sexes · healthy volunteers too.
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30 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 4 · Phase 2 3
First in 2008; this study’s year is marked. 1 started in 2023.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 240 is above the median of 115 across 1,165 interventional studies indexed under Smoking.
Median enrollment 99 across the 29 interventional studies, 117 across the 1 observational. Of the 22 that completed or were terminated, 17 (77%) have results posted.
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Medical University of South Carolina is the lead sponsor of 874 studies on the registry; 165 are open to participants now.
Of its 131 completed or terminated interventional studies of FDA-regulated products, 104 (79%) have results posted.
3 of the studies in Smoking by Medical University of South Carolina that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05019495Medical University of South CarolinaOptimizing Tobacco Treatment Delivery for People Living With HIV | 2027-02-01 |
| NCT06373679Medical University of South CarolinaSwitch or Quit R01 | 2027-05-01 |
| NCT05896033Medical University of South CarolinaImpact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes | 2027-06-30 |
Add all 3 to your calendar (.ics) → With an account.
Among the 30 studies in Smoking by Medical University of South Carolina, from their registry updates:
Nothing recorded among them since 2026-09-25.
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In a 2x2 design, current menthol smokers (N=240) will complete a baseline period before being assigned to a cigarette (menthol or non-menthol) and e-cigarette condition (menthol or tobacco-flavored e-liquid) and receiving a 7-week supply of cigarettes and e-cigarettes. The study builds upon our well-established methodology for simulating tobacco regulatory policies. To model a ban, smokers will be instructed to only use their assigned products. Primary outcomes include cigarette smoking and e-cigarette use during Week 6. However, because a menthol ban may impact the ability to abstain from smoking, the investigators will incentivize participants to abstain from smoking during Week 7 (continued e-cigarette use allowed) and assess the time to first lapse. Participants will complete daily electronic diaries assessing tobacco product use throughout, which will be corroborated by biomarkers for menthol, nicotine, and smoke. Finally, to maximize the utility of these data for FDA regulation, the investigators will assess whether any demographic or baseline smoking characteristics moderate the observed treatment effects, calibrate the treatment effects to the US adult menthol smoking population, and model the effects of menthol regulation in cigarettes and e-cigarettes on smoking and vaping-attributable deaths and life-years lost.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Ppts will be randomly assigned to receive the menthol spectrum cigarettes and Njoy Ace menthol e-cigarettes. Will be used for the duration of the study (8 weeks) starting at the second visit.
Behavioral: Menthol Cigarettes · Behavioral: Menthol Flavored E-cigarettes
Ppts will be randomly assigned to receive the menthol spectrum cigarettes and Njoy Ace tobacco e-cigarettes. Will be used for the duration of the study (8 weeks) starting at the second visit.
Behavioral: Tobacco Flavored E-cigarettes · Behavioral: Menthol Cigarettes
Ppts will be randomly assigned to receive the non-menthol spectrum cigarettes and Njoy Ace menthol e-cigarettes. Will be used for the duration of the study (8 weeks) starting at the second visit.
Behavioral: Non-Menthol Cigarettes · Behavioral: Menthol Flavored E-cigarettes
Ppts will be randomly assigned to receive the non-menthol spectrum cigarettes and Njoy Ace tobacco e-cigarettes. Will be used for the duration of the study (8 weeks) starting at the second visit.
Behavioral: Non-Menthol Cigarettes · Behavioral: Tobacco Flavored E-cigarettes
Ppts will be randomly assigned to a group that receives non-menthol cigarettes
Ppts will be randomly assigned to a group that receives tobacco flavored e-cigarettes
Ppts will be randomly assigned to a group that receives menthol flavored cigarettes
Ppts will be randomly assigned to a group that receives menthol flavored e-cigarettes
Changes in cigarettes per day
Will be measured through week 6 of the study
Time frame: Week 1- Week 6
Fagerstrom Test for Nicotine Dependence
Cigarette Dependence
Time frame: Week 1- Week 7
Ability to abstain from smoking
Participants will complete a 1-week practice quit attempt in week 7; time to first smoking lapse will be assessed.
Time frame: Week 7
Started Oct 2023 (actual). Primary completion is estimated for Jun 2027, 44 months after the start.
Of 402 non-industry interventional studies with no phase under Smoking, half reached primary completion within 26 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 42. This study's planned 44 months is above that.
Counting every sponsor, half of 457 studies reached it within 23 months; a quarter within 8 and three quarters within 40.
How these figures are worked out, and which studies are left out of them.
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Medical University of South Carolina →