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Active, not recruitingNCT05843487Updated May 6, 2023

Association Between Carotid Plaque Length and Cardiovascular Outcomes

An observational study in Coronary Artery Disease and Carotid Plaque, sponsored by Changhai Hospital. Active, not recruiting at 5 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-05-06.

Sponsored by Changhai Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
3,000
Ages
18 Years and older
Sex
All
01

Study summary

This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No. 904 Hospital of the PLA Joint Logistics Support Force Wuxi). The study enrolled 5000 consecutive patients without known CAD who underwent first coronary angiography for stable chest pain and carotid ultrasound was performed during hospitalization from January 2017 through December 2018.

Read the detailed description

Patients who had obstructive CAD (defined as ≥50% luminal stenosis) confirmed by coronary angiography and who underwent carotid scanning were included in the final analysis.Carotid ultrasonography was performed simultaneously, and carotid intima-media thickness (IMT), maximum thickness and length of all plaques were measured.The incidence of major adverse cardiovascular events was recorded during follow-up.

02

Conditions studied

  • Coronary Artery Disease
  • Carotid Plaque

Keywords

  • Carotid Artery Ultrasound
  • Carotid Plaque
  • Coronary Artery Disease
03

In context

Coronary Artery Disease

5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.

This study's planned enrollment of 3,000 is above the median of 336 across 1,947 observational studies indexed under Coronary Artery Disease.

Browse Coronary Artery Disease studies →

Lead sponsor

Changhai Hospital is the lead sponsor of 342 studies on the registry; 133 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Consecutive patients without known CAD who underwent first coronary angiography for stable chest pain and carotid ultrasound was performed during hospitalization.

Inclusion criteria

  • Patients who underwent coronary angiography for stable chest pain and carotid ultrasound simultaneously;
  • Patients with obstructive CAD (≥50% coronary stenosis);

Exclusion criteria

Exclusion Criteria:

  • \<18 years of age;
  • previous carotid surgery or significant carotid artery disease;
  • prior stroke or transient ischemic attack;
  • previously documented CAD (including history of myocardial infarction, acute coronary syndrome, or coronary revascularization);
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
3,000 participants (estimated)
Patient registry
No

Groups and cohorts

  • Carotid plaque length

    Patients underwent carotid ultrasonography and first coronary angiography simultaneously

06

What researchers measure

Primary outcomes

  1. major adverse cardiovascular events

    cardiovascular death, myocardial infarction, ischemic stroke and coronary revascularization

    Time frame: 3 years

Secondary outcomes

  1. all-cause death

    Time frame: 3 years

  2. cardiovascular death

    Time frame: 3 years

  3. myocardial infarction

    Time frame: 3 years

  4. ischemic stroke

    Time frame: 3 years

  5. coronary artery revascularization

    Time frame: 3 years

  6. heart failure

    Time frame: 3 years

07

Study locations

5 sites
  • No. 904 Hospital of the PLA Joint Logistics Support Force
    Wuxi, Jiangsu 214000, China
  • Changhai Hospital
    Shanghai, Shanghai 200000, China
  • Gongli Hospital
    Shanghai, Shanghai 200000, China
  • Putuo Hospital
    Shanghai, Shanghai 200000, China
  • Yueyang Hospital
    Shanghai, Shanghai 200000, China
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 6, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05843487
Lead sponsor
Changhai Hospital
Collaborators
Yueyang Hospital, Shanghai University of Traditional Chinese medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No. 904 Hospital of the PLA Joint Logistics Support Force, Gongli Hospital
Responsible party
Sponsor
First posted
May 6, 2023
Start date
Jan 1, 2017
Primary completion
Mar 31, 2022
Completion
Dec 31, 2030 (estimated)
Last update
May 6, 2023

Study contacts

Pan Li, PhD
principal investigator · Changhai Hospital
Jian Jian Na, MD
study director · Putuo Hospital
Liang Chen, MD
study director · No. 904 Hospital of the PLA Joint Logistics Support Force
Wei Zhang, MD
study director · Gongli Hospital
Yawei Yang, MD
study director · Yueyang Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Jun 2022. You cannot join it, but the record below documents what was studied.

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