An observational study in Coronary Artery Disease, ST Elevation Myocardial Infarction and Ischemic Heart Disease, sponsored by Guy's and St Thomas' NHS Foundation Trust. Active, not recruiting at 3 sites in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-16.
Sponsored by Guy's and St Thomas' NHS Foundation Trust · Observational
Heart attacks caused by the complete blockage of a heart artery are treated by opening it with a stent. However, most people will also have 'non-culprit' narrowings found in their other arteries at this time.
Although in general people do better if these non-culprit narrowings are also treated with stents if they look severe, this process has problems. This is because narrowings that look severe may be stable and not cause any trouble. For these people a stent is a wasted procedure and unnecessary risk. On the other hand, narrowings that are currently left alone because they appear mild, may progress and cause a heart attack.
Participants who have had a heart attack will have a scan from inside the heart arteries during an angiogram (optical coherence tomography, OCT) and a magnetic resonance angiogram (MRA).
If the investigators can show that it is possible to accurately predict which non-culprit narrowings are going to progress and which are going to stabilise, medical professionals may be able to better target their treatments after a heart attack.
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's enrollment of 90 is below the median of 336 across 1,947 observational studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Guy's and St Thomas' NHS Foundation Trust is the lead sponsor of 284 studies on the registry; 79 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients after presentation with ST elevation myocardial infarction.
Exclusion Criteria:
Patients after ST-elevation myocardial infarction with non-culprit coronary artery disease.
Diagnostic Test: Optical coherence tomography and pressure wire assessment · Diagnostic Test: Cardiac magnetic resonance angiogram
Non-culprit coronary arteries
Also known as: OCT (Abbott), PressureWire X (Abbott)
1.5T
Also known as: Cardiac MRI
Change in mean fibrous cap thickness measured by optical coherence tomography
Time frame: 6 months
Change in mean lipid arc measured by optical coherence tomography
Time frame: 6 months
Presence of thin cap fibroatheroma measured by optical coherence tomography
Plaque with lipid arc \>90° and fibrous cap thickness ≤65µm
Time frame: 6 months
Change in measures of shear stress made by optical coherence tomography and magnetic resonance angiography
Comparison between non-invasive and invasively derived measures
Time frame: 0 and 6 months
Non-culprit major adverse cardiac events
Death, myocardial infarction, ischaemia driven revascularisation
Time frame: 6 months and 36 months
Change in vessel stenosis measured by optical coherence tomography and magnetic resonance angiography
Comparison between non-invasive and invasively derived measures
Time frame: 0, 6 and 36 months
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Guy's and St Thomas' NHS Foundation Trust