An observational study in Brain Injury Traumatic Severe and Intracranial Hemorrhage, Hypertensive, sponsored by RenJi Hospital. Recruiting at 1 site in China. Open to participants aged 16 Years to 65 Years. Per ClinicalTrials.gov, last updated 2023-05-03.
Sponsored by RenJi Hospital · Observational
The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients. The main questions it aims to answer is:
2,113 studies on the registry are indexed under Brain Injuries; 385 are open to participants now.
This study's planned enrollment of 10 is below the median of 100 across 690 observational studies indexed under Brain Injuries.
Browse Brain Injuries studies →RenJi Hospital is the lead sponsor of 535 studies on the registry; 244 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with severe traumatic brain injury or hypertensive intracranial hemorrhage.
Exclusion Criteria:
Patients with traumatic brain injury.
Other: Type of disease
Patients with hypertensive intracranial hemorrhage.
Other: Type of disease
Different types of pathogen: brain injury by trauma or intracranial hemorrhage due to hypertension.
RNA biomarkers in TBI or ICH patients' lesion tissues assessed by transcriptome bioinformatic analysis
Patients' lesion tissue will be collected during hematoma evacuation. Then these tissues will be immediately prepared to be detected through transcriptome sequencing. The results of transcriptome sequencing will be further analyzed by bioinformatic analysis to reveal different RNA expressions in lesion tissues of severe TBI and ICH patients as the potential biomarkers.
Time frame: Immediately after collecting tissues
Protein biomarkers in TBI or ICH patients' lesion tissues assessed by proteomic bioinformatic analysis
Patients' lesion tissue will be collected during hematoma evacuation. Then these tissues will be immediately prepared to be detected through proteomics mass spectrometry. The results of proteomic will be further analyzed by bioinformatic analysis to reveal different protein expressions in lesion tissues of severe TBI and ICH patients as the potential biomarkers.
Time frame: Immediately after collecting tissues
Metabolite biomarkers in TBI or ICH patients' lesion tissues assessed by metabolomic bioinformatic analysis
Patients' lesion tissue will be collected during hematoma evacuation. Then these tissues will be immediately prepared to be detected through metabolomic mass spectrometry. The results of metabolomic will be further analyzed by bioinformatic analysis to reveal different metabolite expressions in lesion tissues of severe TBI and ICH patients as the potential biomarkers.
Time frame: Immediately after collecting tissues
Plan to share: No
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