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Status unknownNCT05682833Updated Jan 12, 2023

Adjunctive Use Of A Novel Hyaluronic Acid/Chlorhexidine Gel In The Non Surgical Treatment Of Periodontitis

An interventional study of Non surgical periodontal therapy in Periodontitis, Hyaluronic Acid and Chlorhexidine, sponsored by University of Sharjah. Status unknown at 1 site in United Arab Emirates. Open to participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-01-12.

Sponsored by University of Sharjah · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Jan 2023), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
20 Years to 60 Years
Sex
All
01

Study summary

General Objective :

To evaluate the outcome of non surgical periodontal therapy with local drug delivery adjunct to scaling and root planning

Specific Objective :

To determine the effect of intra-pocket application of hyaluronic acid /chlorohexidine gel in non surgical periodontal treatment on clinical periodontal parameters and microbiological level .

02

Conditions studied

  • Periodontitis
  • Hyaluronic Acid
  • Chlorhexidine

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03

In context

Periodontitis

1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.

This study's planned enrollment of 20 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.

Browse Periodontitis studies →

Lead sponsor

University of Sharjah is the lead sponsor of 41 studies on the registry; 17 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age : 20-60 years old
  • At least 20 remaining teeth
  • Periodontitis stage III and IV ,Grade A, B and C

Exclusion criteria

Exclusion Criteria:

  • Patients taking specific medications: antibiotic , anticoagulants or anti-inflammatory
  • Previous periodontal therapy in the past 3-6 months.
  • Immunocompromised patients
  • Systemically diseased patients: Diabetes ,osteoporosis etc
  • History of allergies or hypersensitivity reactions to chlorohexidine or Hyaluronic acid
  • Pregnant or lactating women.
  • Heavy Smokers (more than 20/day)
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Care provider)
Enrollment
20 participants (estimated)

Study arms

  • Experimental
    Test

    NS therapy + Chlorhexidine/Hyaluronic acid subgingival gel application

    Procedure: Non surgical periodontal therapy

  • Placebo comparator
    Control

    NS therapy + Placebo gel subgingival application

    Procedure: Non surgical periodontal therapy

Interventions

  • ProcedureNon surgical periodontal therapy

    Subgingival ultrasonic debridement + manual root planning

06

What researchers measure

Primary outcomes

  1. pocket depth

    Time frame: 2 months

  2. Bleeding on Probing

    Time frame: 2 months

  3. Clinical attachment level

    Time frame: 2 months

Secondary outcomes

  1. Plaque index

    Time frame: 2 months

07

Study locations

1 of 1 sites recruiting
  • University Dental Hospital Sharjah
    Sharjah, United Arab Emirates
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 12, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05682833
Lead sponsor
University of Sharjah
Responsible party
Zahi BADRAN (Professor, University of Sharjah) — Principal investigator
First posted
Jan 12, 2023
Start date
Oct 1, 2022
Primary completion
Dec 20, 2023 (estimated)
Completion
Jun 20, 2024 (estimated)
Last update
Jan 12, 2023

Study contacts

Prof. Zahi Badran Prof.
Contact
zbadran@sharjah.ac.ae
+97165057353
Zahi BADRAN, Phd
study director · University of Sharjah

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.

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