Corneal Edema clinical trials
The registry lists 39 studies for Corneal Edema across more than 10 countries. 8 are recruiting or about to start. 28 of them are mainly about Corneal Edema (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-09.
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Status
Who runs them
Aurion Biotech (4) · Eye-yon Medical (4) · Nicole Fram M.D. (3) · Emmecell (2) · University Hospital Dubrava (2) · Cornea Research Foundation of America (2) · Alcon Research (2) · Singapore Eye Research Institute (2)
What is being tested here
Drugs under test in Corneal Edema studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| EO2002 | 1 | 0 | 2 |
| Dexamethasone | 0 | 1 | 3 |
| Netarsudil | 0 | 1 | 2 |
| Loteprednol Etabonate | 0 | 0 | 2 |
| Sodium Chloride | 0 | 0 | 2 |
| Prednisolone acetate | 0 | 0 | 2 |
| Prednisolone | 0 | 0 | 2 |
| Triamcinolone | 0 | 1 | 1 |
| Saline Solution | 0 | 0 | 1 |
| Difluprednate | 0 | 0 | 1 |
Drug classes tested here Corticosteroids 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5, phase 3 first
- Jun 2027AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial Dysfunction · Phase 3 · Aurion Biotech
- Dec 2026The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal Dystrophy · University Hospital Dubrava
- Mar 2027PVEK Corneal Implant For Treatment of Corneal Edema · Precise Bio
- Aug 2027Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction · Emmecell
- Oct 2027Plasma Rich in Growth Factors in Corneal Endothelial Transplantation · University of Miami
Who these studies take
Of the 6 Corneal Edema studies recruiting now, 5 (83%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 3 (50%) | 3 (50%) |
| 30 | 6 (100%) | 6 (100%) |
| 40 | 6 (100%) | 6 (100%) |
| 50 | 6 (100%) | 6 (100%) |
| 65 | 6 (100%) | 6 (100%) |
| 75 | 6 (100%) | 6 (100%) |
| 85 | 5 (83%) | 5 (83%) |
Across all 39 studies, recruiting or not: 3% stop at 75 or younger and 3% at 65; 0% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 39 of 39. search them.
- Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial DysfunctionRecruitingNCT07729137Phase 21 country
- The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal DystrophyEnrolling by invitationNCT069695861 country
- Plasma Rich in Growth Factors in Corneal Endothelial TransplantationRecruitingNCT06261346Not applicable1 country
- EndoArt® Implantation in Subjects With Chronic Corneal Edema - US StudyNot yet recruitingNCT07344168Not applicable
- PVEK Corneal Implant For Treatment of Corneal EdemaRecruitingNCT07325097Phase 12 countries
- Study to Assess Safety and Tolerability of Multiple Doses of EO2002RecruitingNCT05636579Phase 11 country
- Validation of the Use of Terahertz Scanning System on Corneal Scars and Corneal EdemaRecruitingNCT069836521 country
- Evaluation of the Safety of Terahertz Scanning System on CorneasRecruitingNCT069677921 country
- AURN001 Efficacy in Participants With Corneal Edema Secondary to Corneal Endothelial DysfunctionActive, not recruitingNCT07368959Phase 31 country
- The Belgian Endothelial Surgical Transplant of the CorneaActive, not recruitingNCT05436665Not applicable1 country
- The Effect of ROCK Inhibitors on Corneas of Patients With Glaucoma and Pseudophakic Bullous Keratopathy (PBK)CompletedNCT06960629Phase 2/31 country
- A Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract SurgeryCompletedNCT05528172Phase 32 countries
- Comparison of 5% Hypertonic Saline Versus 3% Hypertonic Saline in Resolution of Post-operative Corneal Edema.CompletedNCT07605273Not applicable1 country
- Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Cataract SurgeryCompletedNCT05626478Phase 41 country
- A Phase 1/2 Study of AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction (ABA-1)CompletedNCT06041256Phase 1/22 countries
- Study of Safety and Tolerability of EO2002 in the Treatment of Corneal EdemaCompletedNCT04894110Phase 11 country
- Study of Cryopreserved AURN001 in Subjects With Corneal Edema Secondary to Corneal Endothelial DysfunctionActive, not recruitingNCT06630169Phase 21 country
- Air Optix® Night and Day® Aqua Therapeutic WearCompletedNCT059565351 country
- EndoArt® Implantation in Subjects With Chronic Corneal EdemaCompletedNCT05139771Not applicable6 countries
- A Safety and Efficacy Study of Corneal Injection for Endothelial Dysfunction Using Human Corneal Endothelial Cell Therapy in Subjects With Corneal Edema Secondary to Endothelial DysfunctionCompletedNCT05309135Phase 11 country
- Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant RejectionCompletedNCT05136443Phase 41 country
- Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant SurgeryCompletedNCT04521140Phase 41 country
- AONDA Therapeutic Indication Study ICompletedNCT058911061 country
- A Phase 2 Study Evaluating the Safety and Efficacy of Netarsudil Ophthalmic Solution in Patients With Corneal Edema Due to Fuchs Corneal DystrophyCompletedNCT04498169Phase 21 country
- Effect of Intracameral Steroids During Phacoemulsification on the CorneaCompletedNCT05271058Phase 31 country
- Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal EdemaCompletedNCT01890252Not applicable1 country
- A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract SurgeryCompletedNCT049759711 country
- Efficacy and Tolerance of Hypertonic Sodium Chloride (NaCl 5%) Eye Drops Without Preservatives in Corneal EdemaStatus unknownNCT04125394Not applicable1 country
- Eye Drops for Early Morning-Associated Corneal Swelling of the CorneaCompletedNCT04140422Not applicable1 country
- Phase 1 Study to Evaluate the Safety and Tolerability of EO1404 in the Treatment of Corneal EdemaStatus unknownNCT04191629Phase 11 country
- Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal EdemaCompletedNCT02660151Not applicable2 countries
- The Intraocular Pressure Measured by Different Tonometers in Corneal EdemaCompletedNCT019985681 country
- ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial DystrophyCompletedNCT023321091 country
- Study of Eye Bank Pre-cut Donor Grafts for Endothelial KeratoplastyCompletedNCT00624221Not applicable1 country
- Comparison of Corticosteroid Dosing Regimens After Endothelial KeratoplastyCompletedNCT01853696Phase 41 country
- Study of Difluprednate vs. Prednisolone Acetate on Visual Acuity, and Corneal Edema Following Cataract Surgery.CompletedNCT01244334Phase 41 country
- Comparison of DisCoVisc and Hydroxypropylmethylcellulose 2%CompletedNCT01387620Phase 41 country
- A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal EdemaCompletedNCT00346138Not applicable1 country
- Effect of Topical Brimonidine on Post Cataract Surgery Corneal EdemaStatus unknownNCT00800423Phase 31 country