An interventional study of Parietal tACS combined with visuo-attentional training and Sham (placebo) tACS combined with visuo-attentional training in Developmental Dyslexia, sponsored by IRCCS Ospedale San Raffaele. Completed at 1 site in Italy. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-27.
Sponsored by IRCCS Ospedale San Raffaele · Not applicable, Interventional, and Basic science
Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.
Exclusion Criteria:
tACS + visuo-attentional training
Device: Parietal tACS combined with visuo-attentional training
Sham (placebo) tACS + visuo-attentional training
Device: Sham (placebo) tACS combined with visuo-attentional training
Sham (placebo) tACS + phonics training
Device: Sham (placebo) tACS combined with phonics training
Parietal tACS combined with visuo-attentional training
Sham (placebo) tACS combined with visuo-attentional training
Sham (placebo) tACS combined with phonics training
Reading score
Text, word and pseudowords reading score
Time frame: Pre-training, 1-7 days post-training, follow-up at 1 and 6 months
Plan to share: Undecided
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IRCCS Ospedale San Raffaele