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CompletedNCT05583136Updated Jan 27, 2025

Restoring Neural Oscillatory Communication in Developmental Dyslexia

An interventional study of Parietal tACS combined with visuo-attentional training and Sham (placebo) tACS combined with visuo-attentional training in Developmental Dyslexia, sponsored by IRCCS Ospedale San Raffaele. Completed at 1 site in Italy. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-27.

Sponsored by IRCCS Ospedale San Raffaele · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 9 months after the study started (first participant enrolled Dec 2021, registered Oct 2022).
Phase
Not applicable
Study type
Interventional
Enrollment
78
Allocation
Randomized
Ages
18 Years to 35 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 18 studies in Dyslexia with a site in Italy — 7 open to participants now, 7 under way, none of them phase 3. Dyslexia · Italy.

Enrollment
4th of 16
78 · median 48
Started
2021
with 1 other
No phase
16 of 18
7 open now
Registered
12th of 18
by date
Lead sponsor
1 of 18
IRCCS Ospedale San Raffaele

Among the 18 studies in Dyslexia with a site in Italy, this one is the 4th largest by enrollment of the 16 interventional ones, is one of 2 that started in 2021, is one of 16 with no phase, and was the 12th registered.

By phase

18 studies; the count open now beside each. This study's row is marked.

No phasethis study16 · 7 open
Observational2 · 0 open

By the year they started

First in 2016; this study’s year is marked. 2 started in 2021.

Size and results

Median enrollment 48 across the 16 interventional studies, 56 across the 2 observational. Of the 4 that completed or were terminated, 0 (0%) have results posted.

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Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 18 studies in Dyslexia with a site in Italy, or all of them as a file.
02

Study summary

Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.

03

Conditions studied

  • Developmental Dyslexia

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04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult patient (age between 18 and 35)
  • Official Diagnosis of Developmental Dyslexia (DD)
  • Normal or corrected-to-normal vision and hearing
  • Normal motor skills

Exclusion criteria

Exclusion Criteria:

  • Participants that cannot sign the consent form
  • Participants unable to read or understand and correctly complete the procedures foreseen by the study
  • Participants with a diagnosis or personal history of epilepsy or patients with a positive family history of epilepsy
  • Pregnant or breastfeeding patients
  • Participants with major psychiatric or neurological disorders and/or currently in psychopharmacological treatments.
  • Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants.
  • Participants with claustrophobia (only for fMRI)
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
78 participants (actual)

Study arms

  • Experimental
    Group DD1

    tACS + visuo-attentional training

    Device: Parietal tACS combined with visuo-attentional training

  • Active comparator
    Group DD2

    Sham (placebo) tACS + visuo-attentional training

    Device: Sham (placebo) tACS combined with visuo-attentional training

  • Active comparator
    Group DD3

    Sham (placebo) tACS + phonics training

    Device: Sham (placebo) tACS combined with phonics training

Interventions

  • DeviceParietal tACS combined with visuo-attentional training

    Parietal tACS combined with visuo-attentional training

  • DeviceSham (placebo) tACS combined with visuo-attentional training

    Sham (placebo) tACS combined with visuo-attentional training

  • DeviceSham (placebo) tACS combined with phonics training

    Sham (placebo) tACS combined with phonics training

06

What researchers measure

Primary outcomes

  1. Reading score

    Text, word and pseudowords reading score

    Time frame: Pre-training, 1-7 days post-training, follow-up at 1 and 6 months

07

Study locations

1 site
  • Luca Ronconi
    Milan, 20132, Italy
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Dec 2021 to primary completion in Dec 2024, 36 months.

Of 62 non-industry interventional studies with no phase under Dyslexia, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 57. This study's 36 months is above that.

Counting every sponsor, half of 69 studies reached it within 24 months; a quarter within 9 and three quarters within 57.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 7, 2022
First posted
Oct 17, 2022
StartActual
Dec 14, 2021
Primary completionActual
Dec 23, 2024
CompletionActual
Dec 23, 2024
Last update
Jan 27, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jan 27, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05583136
Lead sponsor
IRCCS Ospedale San Raffaele
Responsible party
Luca Ronconi (Professor, IRCCS Ospedale San Raffaele) — Principal investigator
First posted
Oct 17, 2022
Start date
Dec 14, 2021
Primary completion
Dec 23, 2024
Completion
Dec 23, 2024
Last update
Jan 27, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.

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