An observational study in Heart Valve Diseases, sponsored by Hepatopancreatobiliary Surgery Institute of Gansu Province. Completed at 1 site in China. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2024-01-03.
Sponsored by Hepatopancreatobiliary Surgery Institute of Gansu Province · Observational
In this retrospective study, the investigators will analyze the correlation between cardiopulmonary bypass (CPB) time and acute gastrointestinal injury (AGI), and the outcomes of AGI in patients undergoing heart valve replacement.
Patients with heart valve diseases often have chronic cardiac insufficiency. Patients undergoing heart valve replacement with CPB are always complicated with gastrointestinal tract ischemia-reperfusion injury, which usually leads to AGI. AGI after cardiovascular surgery, especially in that use CPB, is associated with significant morbidity and an increase in peri-operative mortality. Prolonged CPB time could be predictive of AGI following heart valve replacement. This study is to analyze the correlation between CPB time and AGI, and the outcomes of AGI in patients undergoing heart valve replacement. The investigators hope that the benefits will include fewer patients becoming seriously postoperative AGI and mortality after cardiac surgery.
535 studies on the registry are indexed under Heart Valve Diseases; 173 are open to participants now.
This study's enrollment of 1,070 is above the median of 300 across 232 observational studies indexed under Heart Valve Diseases.
Browse Heart Valve Diseases studies →Hepatopancreatobiliary Surgery Institute of Gansu Province is the lead sponsor of 41 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Heart valve diseases
Exclusion Criteria:
No intervention, regular therapy
Other: CPB time
No intervention, regular therapy
Other: CPB time
Cardiopulmonary bypass time
Cardiopulmonary bypass (CPB) time
Was defined it as the sum of times of CPB during surgery (minutes).
Time frame: 1 month
The AGI score
The AGI score of the patient within the seventh postoperative day was performed according to the European Society of critical care (2012) guidelines for AGI.
Time frame: 1 month
Number of bowel sounds
The return time of bowel sounds was evaluated morning and evening.
Time frame: 1 month
First defecation time
The time to the first defecation was asked morning and evening after surgery
Time frame: 1 month
Proportion of cocci and bacilli in feces
The first feces were collected in sterile containers for the bacterial smear
Time frame: 1 month
Alanine aminotransferase (ALT)
We defined it as the maximum value of ALT within 7 days after surgery.
Time frame: 1 month
Aspartate aminotransferase (AST)
We defined it as the maximum value of AST within 7 days after surgery
Time frame: 1 month
Left ventricular ejection fraction (LVEF)
We measured the LVEF on the 1st and 3rd days after operation by echocardiographic examinations
Time frame: 1 month
Plan to share: Undecided — If patients permitted
This study is completed, as verified in Jan 2024. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Hepatopancreatobiliary Surgery Institute of Gansu Province