An interventional study of BIPAP mode/SIMV PC mode in Mechanical Ventilation Complication, sponsored by South Valley University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2022-08-02.
Sponsored by South Valley University · Not applicable, Interventional, and Other
Evaluation of biphasic positive airway pressure as a new mode of ventilation in management of acute respiratory failure constituted in ARDS as a category of hypoxaemic respiratory failure in comparison to conventional ventilation.
Biphasic positive airway pressure (BIPAP) is a mode of mechanical ventilation that allow unrestricted spontaneous breathing independent of ventilator cycling, using an active expiratory valve. BIPAP mode is pressure-limited and time-cycled, Ventilation occurs via the time-cycled switching between two set pressure levels. In the absence of spontaneous breathing, this mode resemble conventional pressure controlled ventilation.
A proposed advantage of BIPAP compared to conventional pressure-controlled ventilation is the improved distribution of gas to dependent lung regions as the result of spontaneous breathing enabled during the inspiratory and expiratory time cycles, so prevents atelectasis and promotes alveolar recruitment resulting in an improved ventilation-perfusion matching.
ARDS is an acute diffuse, inflammatory lung injury, leading to increased pulmonary vascular permeability, increased lung weight, and loss of aerated lung tissue with hypoxemia and bilateral radiographic opacities, associated with increased venous admixture, increased physiological dead space and decreased lung compliance.
In patients with ARDS, BIPAP with spontaneous breathing contributes to improved pulmonary gas exchange, systemic blood flow and oxygen supply to the tissue. This is reflected by clinical improvement in the patient's condition, which is associated with significantly fewer days on ventilatory support, earlier extubation and a shorter stay in the intensive care unit.
1,597 studies on the registry are indexed under Respiratory Distress Syndrome; 312 are open to participants now.
This study's enrollment of 40 is below the median of 60 across 961 interventional studies indexed under Respiratory Distress Syndrome.
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Exclusion Criteria:
Mechanically ventilated ARDS patients on BIPAP mode of ventilation
Other: BIPAP mode/SIMV PC mode
Mechanically ventilated ARDS patients on SIMV PC mode of ventilation
Other: BIPAP mode/SIMV PC mode
BIPAP is a mode of ventilation recently used in ARDS
Oxygen saturation of the participants will be measured from the arterial blood gases taken from the patient and according to the range of oxygen saturation from 90 to 98% will be compared
Base line oxygen saturation of BIPAP group and SIMV PC group patients will be taken from the arterial blood gases and recorded from the range of oxygen saturation from 90 to 98% and will be compared between both groups
Time frame: Baseline
Blood pressure in mm Hg of BIPAP group and SIMV PC group will be measured by the sphygmomanometer device
Blood pressure in mm Hg of BIPAP group and SIMV PC group will be measured by the sphygmomanometer device and will be compared between both groups according to the normal range of systolic blood pressure from 90mmHg to 130mmHg and diastolic blood pressure from the range of 60 mmHg to 90 mmHg
Time frame: Base line
Lung mechanics including the tidal volume by ml per kg ideal body weight of BIPAP and SIMV PC groups will be taken from the ventilators and recorded
Lung mechanics including the tidal volume by ml per kg ideal body weight of BIPAP and SIMV PC groups will be taken from the ventilators and compared between both groups according to the range of tidal volume from 4 to 8 ml per kg ideal body weight
Time frame: 24 hours after mechanical ventilation
Duration of mechanical ventilation of BIPAP group
The duration of mechanical ventilation duration had been compared between both groups
Time frame: 6 weeks
The duration of anesthesia in days
The duration of anesthesia in days on BIPAP group willassessed between BIPAP group and SIMV PC group
Time frame: 2 weeks
This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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