An interventional study of Neuromodulation with low-intensity focused ultrasound in Cognitive Change, sponsored by Virginia Polytechnic Institute and State University. Not yet recruiting. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-09.
Sponsored by Virginia Polytechnic Institute and State University · Not applicable, Interventional, and Basic science
Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and cognitive brain signaling using structured tasks. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.
Virginia Polytechnic Institute and State University is the lead sponsor of 124 studies on the registry; 27 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
fMRI resting and cognitive tasks performed after LIFU application to known brain region of interest or active sham region (within participant all conditions tested).
Other: Neuromodulation with low-intensity focused ultrasound
application of LIFU to induce temporary neuromodulation, effects tested with resting state and task based fMRI scanning.
fMRI Signals - Cognition
Changes in fMRI signals of region of interest during a cognitive task
Time frame: Participant study duration, approximately 3 weeks.
Executive function task performance
Testing effects of LIFU on altered task performance
Time frame: Participant study duration, approximately 3 weeks.
Assess for changes in physiological measures
Monitoring for any changes in heartrate, blood pressure, respiratory rate, or galvanic skin response throughout testing
Time frame: Participant study duration, approximately 3 weeks.
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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Virginia Polytechnic Institute and State University