An interventional study of epidural electrical stimulation in Cervical Stenosis, Disk, Herniated and Spondylosis, sponsored by University of California, Los Angeles. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-03-10.
Sponsored by University of California, Los Angeles · Not applicable, Interventional, and Treatment
Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.
144 studies on the registry are indexed under Spondylosis; 41 are open to participants now.
This study's planned enrollment of 150 is above the median of 60 across 99 interventional studies indexed under Spondylosis.
Browse Spondylosis studies →University of California, Los Angeles is the lead sponsor of 1,142 studies on the registry; 192 are open to participants now.
Of its 91 completed or terminated interventional studies of FDA-regulated products, 66 (73%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Epidural Electrical Stimulation of the Cervical Spinal Cord
Device: epidural electrical stimulation
Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia.
Change in respiratory frequency
Increase or decrease in respiratory frequency of 20% during or after stimulation
Time frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation
Change in respiratory tidal volume
Increase or decrease in respiratory tidal volume of 20% during or after stimulation
Time frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation
Change in heart rate
Increase or decrease in heart rate of 20% during or after stimulation
Time frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation
Change in blood pressure
Increase or decrease in blood pressure of 20% during or after stimulation
Time frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation
Plan to share: No
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University of California, Los Angeles