An observational study in Blood Pressure Monitoring, sponsored by Medical University of Graz. Recruiting at 1 site in Austria. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by Medical University of Graz · Observational
The AGREE-BP study aims to evaluate how closely blood pressure measurements taken with an automated upper-arm cuff agree with measurements taken through a small plastic tube placed in an artery, called an arterial catheter, during the start of general anesthesia.
Blood pressure can change rapidly when patients receive medication to induce general anesthesia. These changes may be particularly pronounced in patients with heart or blood vessel disease or high blood pressure. An upper-arm cuff measures blood pressure at intervals, whereas an arterial catheter measures it continuously with each heartbeat. Although cuff measurements are widely used, their agreement with arterial catheter measurements during this period of rapid change is not fully evaluated and validated.
This observational study will include 120 patients undergoing surgery under general anesthesia at University Hospital Graz, Austria. Participants will have conditions that increase their risk of blood pressure changes and will already require an arterial catheter before anesthesia for medical reasons.
During the first five minutes after administration of the medication used to induce anesthesia, researchers will record blood pressure using both methods. The cuff will be placed on the arm opposite the arterial catheter and will take measurements at least once per minute, or more frequently if the monitor allows. Anesthesia and treatment decisions will remain the responsibility of the treating clinician. Participation does not require additional follow-up visits.
The main aim is to assess agreement in mean arterial pressure, which is the average pressure in the arteries over a heartbeat. Researchers will also compare systolic pressure, the pressure when the heart contracts, and diastolic pressure, the pressure when the heart relaxes. They will examine whether patient characteristics or treatments are associated with differences between the two measurement methods and will separately assess agreement during particularly large, rapid blood pressure changes.
The findings may help clinicians understand when cuff measurements differ meaningfully from arterial catheter measurements and inform future decisions about blood pressure monitoring during the start of anesthesia.
Medical University of Graz is the lead sponsor of 470 studies on the registry; 98 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adults patients with a high-risk of hemodynamic changes during induction of anesthesia undergoing general anesthesia induction with clinically indicated intraarterial blood pressure monitoring before induction.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
At least one of the following factors indicating high-risk of blood pressure changes during induction of anesthesia:
Exclusion Criteria:
In addition to intraarterial blood pressure monitoring, non-invasive oscillometric blood pressure monitoring will be performed on the contralateral arm.
Also known as: NIBP
Mean arterial pressure measurement Agreement between IBP and NIBP
Measurement agreement in mean arterial pressure between intraarterial (reference test) and intermittent non-invasive oscillometric (index test) blood pressure monitoring in high-risk patients having induction of anesthesia.
Time frame: In the first five minutes after induction of anesthesia.
Diastolic arterial pressure measurement agreement between IBP and NIBP
Measurement agreement of diastolic arterial pressure between intraarterial (reference test) and intermittent non-invasive oscillometric (index test) blood pressure monitoring in high-risk patients having induction of anesthesia.
Time frame: In the first five minutes after induction of anesthesia.
Systolic arterial pressure measurement Agreement between IBP and NIBP
Measurement agreement of systolic arterial pressure between intraarterial (reference test) and intermittent non-invasive oscillometric (index test) blood pressure monitoring in high-risk patients having induction of anesthesia. Time Frame: In the first five minutes after induction of anesthesia
Time frame: In the first five minutes after induction of anesthesia.
Characteristics associated with disagreement between IBP and NIBP
Patient and/or treatment characteristics associated with pairwise disagreement (\>10 mmHg) between intraarterial (clinical reference) and intermittent non-invasive oscillometric (index test) blood pressure monitoring in high-risk patients having induction of anesthesia.
Time frame: In the first five minutes after induction of anesthesia.
Subgroup Analysis in patients with severe blood pressure changes
In a predefined subgroup analysis, the primary aim and secondary aims 1 and 2 will be evaluated in situations with severe blood pressure changes (a change ≥ 50 mmHg within one minute).
Time frame: In the first five minutes after induction of anesthesia.
Plan to share: Yes — Anonymized data will be shared on reasonable request.
Supporting information: Study protocol
No publications or documents are linked to this record.
Started Oct 2026 (actual). Primary completion is estimated for Sep 2027, 11 months after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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