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CompletedNCT05325918Updated Apr 14, 2022

HIF-1 Alpha, VEGF and MMP-8 Levels in PICF of Smokers Versus Non Smokers

An observational study in Peri-Implantitis, sponsored by Future University in Egypt. Completed at 1 site in Egypt. Open to participants aged 20 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-14.

Sponsored by Future University in Egypt · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
14
Ages
20 Years to 50 Years
Sex
All
01

Study summary

Smoking is a major risk factor for developing peri-implantitis so the current study is comparing inflammatory markers in smokers versus non smokers to know if they have a potential role in pathogenesis of peri-implantitis

Read the detailed description

Peri -implant crevicular fluid was obtained from seven smoker patients and then compared to peri-implant crevicular fluid from seven non smoker individuals.

The peri-implant crevicular fluid was obtained using periopaper strips then analyzed using ELISA kits of these markers; HIF-1 Alpha, VEGF and MMP-8

02

Conditions studied

  • Peri-Implantitis

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Keywords

  • gingival crevicular fluid
  • Smoking
  • inflammation
03

In context

Peri-Implantitis

304 studies on the registry are indexed under Peri-Implantitis; 84 are open to participants now.

This study's enrollment of 14 is below the median of 80 across 116 observational studies indexed under Peri-Implantitis.

Browse Peri-Implantitis studies →

Lead sponsor

Future University in Egypt is the lead sponsor of 97 studies on the registry; 26 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Smoker patients with restored implants

Inclusion criteria

  • Medically free patients
  • Individuals with restored implants placed one year or more before study enrollment
  • Both genders
  • Age range 20-50 years old

Exclusion criteria

Exclusion Criteria:

  • Pregnant Females
  • Lactating females
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
14 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna
06

What researchers measure

Primary outcomes

  1. Measurement of levels of HIF-1 Alpha, VEGF and MMP-8 in peri-implant crevicular fluid

    Markers collected using periopaper strips

    Time frame: Baseline

07

Study locations

1 site
  • Faculty of oral and dental medicine,FUE, Cairo,Egypt
    Cairo, 11835, Egypt
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 14, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05325918
Lead sponsor
Future University in Egypt
Responsible party
Sarah Elkot (Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt., Future University in Egypt) — Principal investigator
First posted
Apr 13, 2022
Start date
Aug 29, 2021
Primary completion
Jan 15, 2022
Completion
Jan 30, 2022
Last update
Apr 14, 2022

Study contacts

Sarah M Elkot, Lecturer
principal investigator · Lecturer of Oral Medicine and Periodontology

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.

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