An interventional study of Estrogen in Adrenal Insufficiency and Hypogonadism Female, sponsored by Rigshospitalet, Denmark. Status unknown at 1 site in Denmark. Open to female participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2022-03-31.
Sponsored by Rigshospitalet, Denmark · Not applicable, Interventional, and Diagnostic
The aim is to investigate impact of exogenous estrogens on cotisol Levels during synacthen stimulation in female hypogonal patients on estrogen substitution. Both patients with and withour adrenal insufficiency will be studied
The aim is to investigate impact of exogenous estrogens on cotisol levels during synacthen stimulation in female hypogonal patients on estrogen substitution. Both patients with and without adrenal insufficiency will be studied . All patients (inclusion criteria age 18-50 years, BMI \<35) will be followed for 6 months and have 3 synacthentests performed: One on transdermal estrogen (minimum 3 months), one on oral estrogens (min 3 months) and one without estrogen substitution for at least 3 months. Primary endpoint is change in serum cortisol 30 minutes after synacthen stimulation
345 studies on the registry are indexed under Hypogonadism; 43 are open to participants now.
This study's planned enrollment of 20 is below the median of 56 across 260 interventional studies indexed under Hypogonadism.
Browse Hypogonadism studies →Rigshospitalet, Denmark is the lead sponsor of 1,017 studies on the registry; 183 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
oral estrogen (2 mg/24 hours)
Drug: Estrogen
Transdermal estrogen (100ug/24 hours)
Drug: Estrogen
Estrogen pause
Transdermal and oral estrogen both as substitution therapy
Change in serum cortisol oral estrogen
Change in serum cortisol 30 minutes after stimulation with synacthen in patients on oral estrogen vs no estrogen substitution
Time frame: Assessment will take place before and 3 months after introduction of the intervention
Change in serum cortisol transdermal estrogen
Change in serum cortisol 30 minutes after stimulation with synacthen in patients on transdermal estrogen vs no estrogen substitution
Time frame: Assessment will take place before and 3 months after introduction of the intervention
This study is status unknown, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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Rigshospitalet, Denmark