ClinicalTrials.gg
RecruitingNCT05218278Updated Mar 30, 2025

NFL Dynamics as a Predictor Factor in Patients With Out of Hospital Cardiac Arrest

An observational study in Out-Of-Hospital Cardiac Arrest and Neurological Injury, sponsored by University Medical Centre Maribor. Recruiting at 1 site in Slovenia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-03-30.

Sponsored by University Medical Centre Maribor · Observational

From the registry’s dates

  • Started Jan 2022; still recruiting 4 years 10 months later.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
60
Ages
18 Years and older
Sex
All
01

Study summary

To investigate the pharmacodynamics of light chain of NFL in patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.

Read the detailed description

To investigate the serum levels of the light chain of NFL at different time points after ICU admission (12, 24, 30, 36, 42, 48 hours after ICU admission) patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.

02

Conditions studied

  • Out-Of-Hospital Cardiac Arrest
  • Neurological Injury
03

In context

Out-of-Hospital Cardiac Arrest

314 studies on the registry are indexed under Out-of-Hospital Cardiac Arrest; 93 are open to participants now.

This study's planned enrollment of 60 is below the median of 300 across 128 observational studies indexed under Out-of-Hospital Cardiac Arrest.

Browse Out-of-Hospital Cardiac Arrest studies →

Lead sponsor

University Medical Centre Maribor is the lead sponsor of 36 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with non-traumatic out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU

Exclusion criteria

Exclusion Criteria:

  • trauma, drowning, electrocution, less than 18 years of age,
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
60 participants (estimated)
Patient registry
No

Groups and cohorts

  • Patients with favorable neurlogical outcome

    CPC 1/2

  • Patients with non-favorable neurological outcome

    CPC3-5

06

What researchers measure

Primary outcomes

  1. The difference in the dynamics of serum NFL levels measurements in patients with favorable neurological outcome compared to patients with non-favorable neurological outcome

    NFL levels

    Time frame: 3 years

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: Undecided — IPD that underlie results in a publication

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 30, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT05218278
Lead sponsor
University Medical Centre Maribor
Responsible party
Matej Strnad (Associate Proffessor, University Medical Centre Maribor) — Principal investigator
First posted
Feb 1, 2022
Start date
Jan 1, 2022
Primary completion
Dec 31, 2026 (estimated)
Completion
Dec 31, 2026 (estimated)
Last update
Mar 30, 2025

Study contacts

Matej Strnad, MD, PhD
Contact
strnad.matej78@gmail.com
+38651225448
Matej Strnad, MD, PhD
principal investigator · University medical cenetr Maribor

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion