An interventional study of lung ultrasound assessment in Acute Respiratory Failure, sponsored by Azienda Ospedaliera di Perugia. Completed at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-01-31.
Sponsored by Azienda Ospedaliera di Perugia · Not applicable, Interventional, and Diagnostic
Second analysis of data prospectively collected during an investigation assessing the clinical characteristics of patients admitted for hypoxemic acute respiratory failure (hARF) related to novel coronavirus 19 disease (COVID-19). In particular, the primary aim of the present analysis is to assess the effects of recruiting maneuver and prone positioning on lung aeration evaluated through lung ultrasound in patients undergoing invasive mechanical ventilation
1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.
This study's enrollment of 25 is below the median of 55 across 1,043 interventional studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →Azienda Ospedaliera di Perugia is the lead sponsor of 13 studies on the registry; 4 are open to participants now.
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Inclusion Criteria: Patients intubated for COVID-19 hARF -
Exclusion Criteria: Any contraindication to recruitment and lung ultrasound, pregnancy
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n patients undergoing invasive mechanical ventilation with an arterial oxygen tension on inspired oxygen fraction ratio \< 200 mmHg requiring recruitment maneuver and prone positioning as a rescue therapy, lung aeration will be evaluated at: baseline, in supine position under protective ventilation after two minute of recruitment maneuver in pressure controlled ventilation at 1 hour following prone positioning application
Other: lung ultrasound assessment
In patients undergoing invasive mechanical ventilation with an arterial oxygen tension on inspired oxygen fraction ratio \< 200 mmHg requiring recruitment maneuver and prone positioning as a rescue therapy, lung aeration will be evaluated at: 1. baseline, in supine position under protective ventilation 2. after two minute of recruitment maneuver in pressure controlled ventilation 3. at 1 hour following prone positioning application
lung ultrasound score
lung aeration evaluated through ultrasound during protective invasive mechanical in supine position. Lung ultrasound score ranges from a minimum of 0 to a maximum of 36, where 0 is the best lung aeration and 36 is the worst lung aeration
Time frame: after 20 minutes following study entry, in volume controll ventilation and supine position
lung ultrasound score recruitment
lung aeration evaluated through ultrasound during protective invasive mechanical ventilation in supine position after two minutes of recruiting maneuver in pressure controlled ventilation. Lung ultrasound score ranges from a minimum of 0 to a maximum of 36, where 0 is the best lung aeration and 36 is the worst lung aeration
Time frame: 2 minutes
lung ultrasound score prone positioning
lung aeration evaluated through ultrasound during protective invasive mechanical ventilation after 1 h from prone position application. Lung ultrasound score ranges from a minimum of 0 to a maximum of 36, where 0 is the best lung aeration and 36 is the worst lung aeration
Time frame: 1 hour
Plan to share: Undecided
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This study is completed, as verified in Jan 2024. You cannot join it, but the record below documents what was studied.
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Azienda Ospedaliera di Perugia