An observational study in Stroke, sponsored by Fondation Hôpital Saint-Joseph. Status unknown at 2 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-09-13.
Sponsored by Fondation Hôpital Saint-Joseph · Observational
Stroke is a public health issue and a priority for our institution. MRI plays an essential role in the management of stroke. In this context, the contribution of MRI is diagnostic, etiological and prognostic.
Among the MRI parameters evaluated in the acute phase of the stroke, the evaluation of the mismatch between the DIFFUSION and FLAIR sequences is crucial as it will directly contribute to the therapeutic decision. A FLAIR-diffusion mismatch, i.e., a lesion with a diffusion but not a FLAIR hypersignal, identifies patients whose time of onset of symptoms is probably less than 4.5 hours. It is therefore understandable that the main arterial recanalization techniques performed in the acute phase are primarily reserved for patients with a positive mismatch.
In current practice, mismatch assessment is performed subjectively, by visually comparing the two sequences, which is known to be the cause of a lack of reproducibility and diagnostic performance.
Computational medical imaging techniques ("radiomics") have recently gained momentum and offer the prospect of automated and therefore more reproducible analysis of medical imaging data. In stroke patients, radiomics extracted from FLAIR imaging could thus contribute to describe the "diffusion flair" mismatch in a continuous and objective way.
For the time being, data analysis cannot be performed in real time due to technical constraints. If it is proven that radiomics can reliably analyze the mismatch on the FLAIR sequence alone, the next step will be to make the analysis feasible in clinical routine (i.e. in a time frame adapted to the therapeutic management).
7,443 studies on the registry are indexed under Stroke; 2,012 are open to participants now.
This study's planned enrollment of 35 is below the median of 160 across 1,729 observational studies indexed under Stroke.
Browse Stroke studies →Fondation Hôpital Saint-Joseph is the lead sponsor of 344 studies on the registry; 49 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients referred for suspected stroke between January 1, 2016 and May 1, 2021 at Paris Saint Joseph Hospital.
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Exclusion Criteria:
ability of a computational medical imaging technique ("radiomics"), performed on the FLAIR sequence alone, to predict the FLAIR diffusion mismatch in patients with ischemic stroke
This outcome corresponds to FLAIR / Diffusion mismatch scores estimated with both techniques: automated and visual analysis.
Time frame: Day 1
Inter-technique comparison of mismatch assessment between automated "radiomics" analysis and subjective visual analysis (currently performed in clinical routine)
This outcome corresponds to the reproducibility and inter-technical agreement on the extent of the mismatch.
Time frame: Day 1
Evaluation of the prognostic value of the scores obtained with the two methods
This outcome corresponds to the correlation of the scores obtained with the Rankin score at 3 months.
Time frame: Month 3
This study is status unknown, as verified in Sep 2023. You cannot join it, but the record below documents what was studied.
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