An interventional study of Blood Flow Restriction and Standard of Care in Training Study, Multiple Sclerosis and Blood Flow Restriction, sponsored by University of Central Florida. Completed at 1 site in United States. Open to female participants aged 18 Years to 55 Years. Per ClinicalTrials.gov, last updated 2024-06-11.
Sponsored by University of Central Florida · Not applicable, Interventional, and Treatment
This research is being done to compare the current standard of care for strength training for patients with Multiple Sclerosis to lightweight resistance training with blood flow restriction.
The purpose of this study is to compare the effectiveness of the current Multiple Sclerosis standard of care exercise recommendations to low-load resistance training with blood flow restriction on functional outcomes, strength, muscle size, and neuromuscular control in Multiple Sclerosis patients. This study involves completing 2 training sessions per week for 12 weeks as well as pre- and post-training assessment visits for a total of 29 visits over 14 weeks. All visits will be on UCF's campus with a member of the research team.
3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.
This study's enrollment of 20 is below the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.
Browse Multiple Sclerosis studies →University of Central Florida is the lead sponsor of 99 studies on the registry; 40 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The BFR group will complete 1 set of 30 (1 x 30) at 30% of their 1 repetition maximum for leg press, leg extension, leg curl, chest press, seated row, and shoulder press completed on exercise machines with 2 minutes between exercises.
Other: Blood Flow Restriction
The standard of care group will complete 1 set of 8-12 repetitions at 60-80% of their 1 repetition maximum for leg press, leg extension, leg curl, chest press, seated row, and shoulder press completed on exercise machines with 2 minutes between exercises.
Other: Standard of Care
Resistance training with BFR
Resistance Training with no BFR
Change in Functional Outcomes- 10meter
determined via changes in 10 meter walk test, measured by how fast (in minutes and seconds) someone can walk 10 meters
Time frame: Day 2, Week 4 and 8, Day 28
Change in Functional Outcomes- 6min walk
determined via changes in 6 minute walk test, measured by how far (in feet) someone can walk in 6 minutes
Time frame: Day 2, Week 4 and 8, Day 28
Change in Functional Outcomes- CST
determined via changes in sit-to-stand test, measured by how quickly someone can stand from a seated position
Time frame: Day 2, Week 4 and 8, Day 28
Change in Functional Outcomes- 30CST
determined via changes in 30 second sit-to-stand, measured by how many times someone can stand from a seated position in 30 seconds
Time frame: Day 2, Week 4 and 8, Day 28
Change in Functional Outcomes- MFIS
determined via changes in Modified Fatigue Impact Scale Questionnaire, sum score of answers on the questionnaire
Time frame: Day 2, Week 4 and 8, Day 28
Changes in Strength
determined via maximal voluntary contractions on the Biodex
Time frame: Day 3, Week 4 and 8, Day 29
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.
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University of Central Florida