An interventional study of Imiquimod treatment and Local Hyperthermia at 44℃ in Human Papilloma Virus, sponsored by First Hospital of China Medical University. Status unknown at 1 site in China. Open to participants aged 12 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-12-07.
Sponsored by First Hospital of China Medical University · Not applicable, Interventional, and Treatment
flat warts are a superficial viral skin disease, extremely common in childhood.Treatment of warts is often difficult and involves different destructive procedures.Although several pharmacological and physical topical treatments are available (keratolytic agents, electrosurgery, cryotherapy, carbon dioxide laser), results are often unsatisfactory in terms of efficacy (frequent recurrence) and cosmetic outcome (scars, inflammatory reactions, transient or permanent hyper- or hypopigmentation).
Mild local Hyperthermia with a certain temperature range has been successfully used in the treatment of some diseases. It has been utilised in the treatment of some neoplasm, fungal and HPV infections. Investigators' study found that local hyperthermia at 44°C could cleared HPV in more than half of the patients with plantar warts. Investigators also note the fact that in patients with multiple lesions, the clearance of the target lesion is commonly followed by clearance of other distant lesions, a phenomenon suggesting that local hyperthermia could aid in establishing a specific immune response to eliminate HPV.So the purpose of the study is to evaluation local hyperthermia in the treatment of flat warts Appropriate control arms were designed for different conditions.
234 studies on the registry are indexed under Papilloma; 28 are open to participants now.
This study's planned enrollment of 60 is below the median of 100 across 159 interventional studies indexed under Papilloma.
Browse Papilloma studies →First Hospital of China Medical University is the lead sponsor of 59 studies on the registry; 32 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Local hyperthermia at 44℃ for 30 mins on one lesion region, at days of 1,2,3, 15, 16, 21 and 28.
Device: Local Hyperthermia at 44℃
Miquimod treatment: 3 times a week for 1 month
Drug: Imiquimod treatment
As an control arm, for patients with flat warts
As an experimental arm, for patients with flat warts
clearance rates of HPV
to evaluate the clearance rates of all lesions in different treatment groups 3 month after treatment.
Time frame: 3 months after the last time of treatment
effective rates of HPV
to evaluate the effective rates of all lesions in different treatment groups 3 month after treatment.
Time frame: 3 months after the last time of treatment
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Nov 2021. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
First Hospital of China Medical University