A Phase 2/3 interventional study of Propolis nanoparticles extract solution and sodium hypochlorite in Necrotic Pulp, sponsored by Cairo University. Status unknown. Open to participants aged 20 Years to 55 Years. Per ClinicalTrials.gov, last updated 2021-12-07.
Sponsored by Cairo University · Phase 2/3, Interventional, and Treatment
The aim of this study is to clinically compare the intensity of post-operative pain and the amount of bacterial reduction after using 20mg/ml propolis nanoparticles extract solution during chemo-mechanical preparation, versus 2.5% NaOCl, in asymptomatic necrotic mandibular premolars treated in a single visit.
149 studies on the registry are indexed under Dental Pulp Necrosis; 39 are open to participants now.
This study's planned enrollment of 44 is close to the median of 44 across 139 interventional studies indexed under Dental Pulp Necrosis.
Browse Dental Pulp Necrosis studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Teeth with:
Dietary Supplement: Propolis nanoparticles extract solution
Drug: sodium hypochlorite
20 mg/ml propolis nanoparticles in the form of solution prepared from honeybee from various plants.
2.5% sodium hypochlorite (household bleaching agent)
Postoperative pain
postoperative pain will be marked by the patient using the Numerical rating scale (NRS) chart which is an 11 point scale consisting of numbers from 0 through 10, where: 0: reading represents "no pain" 1-3: readings represent "mild pain" 4-6: readings represent "moderate pain" 7-10: readings represent "severe pain"
Time frame: up to 48 hours postoperatively
Intracanal bacterial load change
The intracanal bacterial load change will be determined using agar culture technique by counting the colony forming units per milliliter (CFUs/mL) before and after root canal preparation.
Time frame: Throughout the chemo-mechanical preparation of the canal.
Number of analgesic tablets taken by the patient after endodontic treatment
Time frame: Up to 48 hours postoperative.
No study locations are listed for this record.
This study is status unknown, as verified in Dec 2021. You cannot join it, but the record below documents what was studied.
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Cairo University