An interventional study of Exercise in Essential Hypertension, sponsored by University of British Columbia. Completed at 1 site in Canada. Open to participants aged 40 Years to 70 Years. Per ClinicalTrials.gov, last updated 2024-08-12.
Sponsored by University of British Columbia · Not applicable, Interventional, and Treatment
The investigators are investigating the effects of traffic-related air pollution (TRAP) on the cardiovascular and pulmonary response to exercise in patients with hypertension using a real world randomized, crossover study design. Participants will be exposed to 2 conditions: a low TRAP environment and a high TRAP environment. Each exposure will consist of 30 min of moderate-intensity exercise. Cardiovascular and pulmonary health outcomes will be measured before, during, and up to 24 hours following exposures. A minimum washout period of 1 week will be used to minimize carryover effects.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's enrollment of 21 is below the median of 90 across 4,995 interventional studies indexed under Hypertension.
Browse Hypertension studies →University of British Columbia is the lead sponsor of 1,309 studies on the registry; 253 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will exercise in an environment with high levels of traffic-related air pollution first. Afterwards, participants will complete the same exercise in an environment with low levels of traffic-related air pollution.
Behavioral: Exercise
Participants will exercise in an environment with low levels of traffic-related air pollution first. Afterwards, participants will complete the same exercise in an environment with high levels of traffic-related air pollution.
Behavioral: Exercise
Participants will engage in moderate-intensity (40-59% HRR) exercise for 30 min
Change from Baseline Blood Pressure at 2 Hours Post-Exposure
MAP, SBP, and DBP
Time frame: Baseline and 2 hours post-exposure
24-Hour Blood Pressure
MAP, SBP, and DBP
Time frame: 24 hours post-exposure
Heart Rate Variability
Indices of heart rate variability
Time frame: Baseline and up to 24 hours post-exposure
Change from Baseline Arterial Stiffness at 2 Hours Post-Exposure
Pulse wave velocity and augmentation index
Time frame: Baseline and 2 hours post-exposure
Change from Baseline Microvascular Responsiveness at 2 Hours Post-Exposure
Microvascular responsiveness (measured by near-infrared spectroscopy)
Time frame: Baseline and 2 hours post-exposure
Muscle Oxygen Saturation
Muscle oxygen saturation (measured by near-infrared spectroscopy)
Time frame: Continuously throughout the 30 minute exercise bouts (during exposure)
Change from Baseline FEV1 and FVC at 2 Hours Post-Exposure
Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) measured by spirometry (in L)
Time frame: Baseline and 2 hours post-exposure
Change from Baseline FEV1/FVC at 2 Hours Post-Exposure
FEV1/FVC ratio measured by spirometry
Time frame: Baseline and 2 hours post-exposure
Change from Baseline FEF25-75 and PEFR at 2 Hours Post-Exposure
Forced expiratory flow at 25-75% of forced vital capacity (FEF25-75) and peak expiratory flow rate (PEFR) measured by spirometry (in L/s)
Time frame: Baseline and 2 hours post-exposure
Severity of Symptoms
Severity of respiratory symptoms (e.g., dyspnea, cough, wheeze, chest tightness) and headache on a 0-5 scale
Time frame: Baseline and 2 hours post-exposure
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2024. You cannot join it, but the record below documents what was studied.
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University of British Columbia