An observational study in Cirrhosis, Liver, Cardiomyopathies and Portal Hypertension, sponsored by University Hospital, Bonn. Completed at 2 sites in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-09-16.
Sponsored by University Hospital, Bonn · Observational
The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients with liver cirrhosis after implantation of transjugular intrahepatic portosystemic shunt (TIPS).
1,642 studies on the registry are indexed under Liver Cirrhosis; 358 are open to participants now.
This study's enrollment of 13 is below the median of 151 across 587 observational studies indexed under Liver Cirrhosis.
Browse Liver Cirrhosis studies →University Hospital, Bonn is the lead sponsor of 154 studies on the registry; 30 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Primary care clinic (Department of Internal Medicine I, University Hospital Bonn, Germany)
Exclusion criteria:
Patients with cirrhosis and transjugular intrahepatic portosystemic shunt implantation.
Procedure: Transjugular intrahepatic portosystemic shunt implantation · Diagnostic Test: Magnetic resonance imaging
Transjugular intrahepatic portosystemic shunt is an artificial channel within the liver that establishes communication between the inflow portal vein and the outflow hepatic vein. It is used to treat portal hypertension (e.g., in liver cirrhosis)
Multiparametric cardiac and hepatic magnetic resonance imaging
Myocardial T1 relaxation time
T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\].
Time frame: Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.
Myocardial T2 relaxation time
T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\].
Time frame: Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.
Myocardial ECV
Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\].
Time frame: Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.
Plan to share: No
This study is completed, as verified in Sep 2021. You cannot join it, but the record below documents what was studied.
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University Hospital, Bonn