An interventional study of Stationary Bike + Blood-Flow-Restriction and Stationary Bike + Sham-Blood-Flow-Restriction in Sarcopenia in Elderly, sponsored by University Hospital, Bonn. Recruiting at 1 site in Germany. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-10-05.
Sponsored by University Hospital, Bonn · Not applicable, Interventional, and Treatment
Background: Older adults have a reduced ability to build and maintain muscle mass due to age-related changes in the muscular system. The resulting sarcopenia can lead to a number of health problems and limitations, such as an increased risk of falling and reduced mobility, which can affect quality of life and increase the risk of disease. To increase muscle mass and strength, high-intensity resistance training with loads of 70 to 85% of the repetition maximum (1RM) is recommended. However, this type of training poses a major challenge in the rehabilitation sector, as there is also an increased risk of injury due to physical limitations in old age. According to current research, low-intensity occlusion training could therefore represent a safe and effective training alternative. The aim of this study is therefore to examine the feasibility and effects of blood flow restriction training (BFR) on general health in older adults in a rehabilitative setting.
The study is a randomized controlled trial with a pre-post design. Participants will be recruited from the of St. Marien Hospital Geriatric Rehabilitation Center in Cologne, Germany. Patients will be randomized into 2 groups. The intervention group will receive BRF training on a stationary cycling ergometer five times a week over a period of two weeks, while the control group will receive sham-BFR training.
1,329 studies on the registry are indexed under Sarcopenia; 420 are open to participants now.
This study's planned enrollment of 90 is above the median of 60 across 855 interventional studies indexed under Sarcopenia.
Browse Sarcopenia studies →University Hospital, Bonn is the lead sponsor of 154 studies on the registry; 28 are open to participants now.
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Exclusion Criteria:
Acute geriatric rehabilitation + Blood-Flow-Restriction Training
Device: Stationary Bike + Blood-Flow-Restriction
Acute geriatric rehabilitation + Sham-Blood-Flow-Restriction Training
Device: Stationary Bike + Sham-Blood-Flow-Restriction
Acute geriatric rehabilitation/ Standard of Care
Procedure: Acute geriatric rehabilitation + No additional Intervention
Cycling Intensity individualized + 60% LOP
Cycling Intensity individualized + 20mmHg
Acute geriatric rehabilitation + No additional intervention
Muscle Strength
Isometric Maximal Strength Test of the Knee Extensors (in kg)
Time frame: Pre-Rehabilitation to Post-Rehabilitation (after 2 weeks)
Timed Up and Go Test
The Timed Up and Go Test (TUG) is a widely used English-language assessment for measuring functional mobility and fall risk in older adults. It records the time required to stand up from a chair, walk three meters, turn around, and sit down again.
Time frame: Pre-Rehabilitation to Post-Rehabilitation (after 2 Weeks)
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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