An interventional study of CogMed in Opioid Use, Cognitive Change and Opioid-use Disorder, sponsored by New York State Psychiatric Institute. Terminated at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-03-04.
Sponsored by New York State Psychiatric Institute · Not applicable, Interventional, and Treatment
This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose and cognitive functioning. This study will also examine the impact of computerized working memory training on relevant outcomes (cognition, psychosocial functioning, quality of life, drug use). The training component of the study lasts 1 month, with follow up visits and 1-month and 3-months post training.
This outpatient study is designed to examine the potential relationship between non-fatal opioid overdose (i.e. overdose that does not result in death), cognitive functioning, and the impact of computerized working memory training on relevant outcomes (cognition, psychosocial functioning, quality of life). Participants (n=30) with a history of at least one prior opioid OD, who are enrolled in buprenorphine treatment, will be randomized to 20 sessions of an active (n=15) or sham (n=15) working memory training. Patients will complete measures of cognitive functioning during screening, post-training, and at 1-month and 3-month follow up. Participants will also complete the measures of decision making, psychosocial functioning and drug use at baseline, post-training, and follow up.
1,411 studies on the registry are indexed under Opioid-Related Disorders; 290 are open to participants now.
This study's enrollment of 13 is below the median of 63 across 1,123 interventional studies indexed under Opioid-Related Disorders.
Browse Opioid-Related Disorders studies →New York State Psychiatric Institute is the lead sponsor of 425 studies on the registry; 26 are open to participants now.
Of its 50 completed or terminated interventional studies of FDA-regulated products, 45 (90%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Working memory training with task-difficulty increasing across sessions
Other: CogMed
Working memory training with task-difficulty remaining constant across sessions.
Other: CogMed
20 sessions of Cogmed working memory training
NIH Toolbox Cognition Battery
A brief computerized test of key neuropsychological functions
Time frame: Post-Training (1-month from baseline)
NIH Toolbox Cognition Battery
A brief computerized test of key neuropsychological functions
Time frame: 1-month Follow up
NIH Toolbox Cognition Battery
A brief computerized test of key neuropsychological functions
Time frame: 3-month Follow up
Psychosocial Functioning (Brief Inventory of Psychosocial Functioning B-IPF)
B-IPF: scores range from 0 to 49 with higher scores indicating greater difficulties with psychosocial functioning
Time frame: Post-training (1 month from baseline)
Psychosocial Functioning (Brief Inventory of Psychosocial Functioning B-IPF)
B-IPF: scores range from 0 to 49 with higher scores indicating greater difficulties with psychosocial functioning
Time frame: 1-month follow up
Psychosocial Functioning (Brief Inventory of Psychosocial Functioning B-IPF)
B-IPF: scores range from 0 to 49 with higher scores indicating greater difficulties with psychosocial functioning
Time frame: 3-month follow up
Illicit Substance Use: Timeline Follow Back (TLFB)
TLFB: measures substance use in the past 1-week period
Time frame: Post-training (1-month from baseline)
Illicit Substance Use: Timeline Follow Back (TLFB)
TLFB: measures substance use in the past 1-week period
Time frame: 1-month follow up
Illicit Substance Use: Timeline Follow Back (TLFB)
TLFB: measures substance use in the past 1-week period
Time frame: 3-month follow up
Quality of Life Scale (QOLS)
QOLS: scores range from 16 to 112 with higher scores indicating greater quality of life
Time frame: Post-training (1 month from baseline)
Quality of Life Scale (QOLS)
QOLS: scores range from 16 to 112 with higher scores indicating greater quality of life
Time frame: 1-month follow up
Quality of Life Scale (QOLS)
QOLS: scores range from 16 to 112 with higher scores indicating greater quality of life
Time frame: 3-month follow up
Impulsive decision making (Delay Discounting Task)
Delay Discounting Task
Time frame: Post-training (1 month from baseline)
Impulsive decision making (Delay Discounting Task)
Delay Discounting Task
Time frame: 1-month follow up
Impulsive decision making (Delay Discounting Task)
Delay Discounting Task
Time frame: 3-month follow up
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Plan to share: No
This study is terminated, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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New York State Psychiatric Institute