An interventional study of Polyethylene Glycol 400 0.4%-Propylene Glycol 0.3%. and Dextran 0.1%Hypromellose 0.3%, in Dry Eye Disease, sponsored by University of Faisalabad. Status unknown at 1 site in Pakistan. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-07-21.
Sponsored by University of Faisalabad · Not applicable, Interventional, and Treatment
The purpose of this research is to the determine effect of dry eye and to compare the effect of artificial tears on central and peripheral corneal thickness.
In this randomized controlled trial, 96 eyes of females with dry eye will be recruited through random sampling. Dry eye assessments will be done including TBUT, Schirmer test 1, and OSDI questionnaire. 96 eyes will be divided into 3 groups (32 eyes each) and will be provided intervention which is Polyethylene Glycol 400 0.4%-Propylene Glycol 0.3%. , Dextran 0.1%Hypromellose 0.3%, and placebo(normal saline) through randomization by an unmasked investigator. Changes in central and peripheral corneal thickness will be evaluated by corneal topography. Patients will be evaluated at baseline, after 15 days, after 1 month, and re-evaluated after 1 month of cessation of treatment.
1,292 studies on the registry are indexed under Dry Eye Syndromes; 191 are open to participants now.
This study's planned enrollment of 96 is above the median of 60 across 1,077 interventional studies indexed under Dry Eye Syndromes.
Browse Dry Eye Syndromes studies →University of Faisalabad is the lead sponsor of 83 studies on the registry; 26 are open to participants now.
Counted across the registry records on this site, refreshed daily.
● Females with ages ranging between 18-40 years and OSDI scores greater than 13, ametropia of up to 1DS of SE with astigmatism of less than 0.5DC, and Emmetropes.
Exclusion Criteria:
Instill one drop three times a day for one month.
Drug: Polyethylene Glycol 400 0.4%-Propylene Glycol 0.3%. and Dextran 0.1%Hypromellose 0.3%,
Instill one drop three times a day for one month.
Drug: Polyethylene Glycol 400 0.4%-Propylene Glycol 0.3%. and Dextran 0.1%Hypromellose 0.3%,
Instill one drop three times a day for one month.
Drug: Polyethylene Glycol 400 0.4%-Propylene Glycol 0.3%. and Dextran 0.1%Hypromellose 0.3%,
Drugs will be given to two group and third group will kept on placebo.
Also known as: Systane and Tears Naturale 2
Change in Corneal Thickness in microns
effect of dry eye treatment on the thickness of the cornea in microns measured by using corneal topography.
Time frame: one month
Change in Corneal Thickness in microns after treatment discontinuation.
after on month of treatment discontinuation access the change in corneal thickness in microns by using corneal topography.
Time frame: one month
Improvement in dry eye
after treatment with artifical tears improvement in the tear break-up time in seconds and schirmer test values in millimeters.
Time frame: one month
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Jul 2021. You cannot join it, but the record below documents what was studied.
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University of Faisalabad