An interventional study of Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baseline and Active isolated stretching (AIS) in Upper Limb Overuse Syndrome, sponsored by University of Faisalabad. Recruiting at 1 site in Pakistan. Open to participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-07-14.
Sponsored by University of Faisalabad · Not applicable, Interventional, and Treatment
Upper-limb overuse syndrome (ULOS) often arises from repetitive loading, altering cervical biomechanics and increased median-nerve mechano sensitivity. Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) at C5-C6 improves segmental decompression and neural sliding, while Active isolated stretching (AIS) enhances soft tissue elasticity and neuro dynamic glide.
Currently no direct comparison exists between these two methods in literature. Study aims to compare ELDOA (C5-C6 specific) and AIS in patients with ULOS for checking effects on median nerve mobility and pain. This research will be conducted as a randomized clinical trial involving 84 participants (42 in each group). Adults aged 20-50 years with diagnosis of ULOS, symptom duration 3- months (12 weeks) will be included in the study. While Neurological or rheumatologic conditions, recent corticosteroid injections, recent cervical or major upper limb surgery, and ongoing neural mobilization-focused physical therapy are among the exclusions. After meeting the inclusion and exclusion criteria and obtaining written and verbal consent from the participants. Participants will be randomly assigned to either the AIS or ELDOA groups and will receive 3 sessions per week for 3 weeks with baseline hot pack. Group A will perform diaphragmatic breathing with ELDOA targeting C5-C6, whereas Group B will engage in AIS on muscles that cause median-nerve tension. Pain intensity, upper limb function and median nerve mobility are outcome measures that will be assessed using tools NPRS, QuickDASH and ULTT1. Data will be analyzed using the 2024 SPSS.
43 studies on the registry are indexed under Cumulative Trauma Disorders; 8 are open to participants now.
This study's planned enrollment of 84 is above the median of 64 across 25 interventional studies indexed under Cumulative Trauma Disorders.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
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Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
1. Hot pack application • A moist hot pack will be applied to the cervical and upper-limb region for 10 minutes prior to the main intervention. 2. Patient education 3. Home exercise program Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) C5-C6 spinal segments will be the focus of ELDOA postures performed by participants assigned to ELDOA group. To improve neuromuscular engagement, each pose will be held for 30 seconds and performed five times while accompanied by guided diaphragmatic breathing. Each session of ELDOA intervention will last roughly 15 to 20 minutes in total. To optimize therapeutic efficacy and safety, the therapist will closely monitor symptoms during each session and make sure that each posture is executed and aligned correctly.
Procedure: Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) and baseline
1. Hot pack application • A moist hot pack will be applied to the cervical and upper-limb region for 10 minutes prior to the main intervention. 2. Patient education 3. Home exercise program Active isolated stretching (AIS) Active Isolated stretches that target the wrist flexors, pronator teres, biceps and pectoralis minor muscles that affect median nerve tension will be performed by participants assigned to the AIS group 3 set of 8 to 10 repetitions of each stretch, held for two seconds, will be performed for every muscle group. Each session of AIS intervention will last roughly 15 to 20 minutes in total to maximize safety and efficacy. The therapist will keep an eye on technique, make sure that proper activation is occurring and evaluate stretch tolerance throughout the intervention.
Procedure: Active isolated stretching (AIS)
Common baseline treatment (both Groups) Prior to their designated intervention, both groups will receive the following standardized baseline treatment: 1. Hot pack application 2. Patient education 3. Home exercise program Elongation longitudinal decoaptation ostéo-articulaire (ELDOA) C5-C6 spinal segments will be the focus of ELDOA postures performed by participants assigned to ELDOA group. To improve neuromuscular engagement, each pose will be held for 30 seconds and performed five times while accompanied by guided diaphragmatic breathing. Each session of ELDOA intervention will last roughly 15 to 20 minutes in total. To optimize therapeutic efficacy and safety, the therapist will closely monitor symptoms during each session and make sure that each posture is executed and aligned correctly.
1. Hot pack application 2. Patient education. 3. Home exercise program Active isolated stretching (AIS) Active Isolated stretches that target the wrist flexors, pronator teres, biceps and pectoralis minor muscles that affect median nerve tension will be performed by participants assigned to the AIS group 3 set of 8 to 10 repetitions of each stretch, held for two seconds, will be performed for every muscle group. Each session of AIS intervention will last roughly 15 to 20 minutes in total to maximize safety and efficacy. The therapist will keep an eye on technique, make sure that proper activation is occurring and evaluate stretch tolerance throughout the intervention.
Pain intensity
Pain intensity will be measured by using numeric pain rating scale
Time frame: 3 weeks
Functional status/ Disability
Functional status/ Disability will be measured by using QuickDASH questionnaire, The lower the Quick DASH score, the better the upper limb function and fewer the activity limitations.
Time frame: 3 weeks
Nerve mobility
Nerve mobility will be measured by using Upper Limb Tension Test (ULTT1), Better responses in the ULTT1 suggest better median nerve mobility and lower neural tension.
Time frame: 3 weeks
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