An observational study in Syncope and Seizures, sponsored by Ruhr University of Bochum. Status unknown at 4 sites in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-05-21.
Sponsored by Ruhr University of Bochum · Observational
Changes of thyroid function may occur after short loss of consciousness, but they haven't been systematically evaluated up to now, although occasional observations suggest temporal increases in TSH concentration.
This study aims at assessing transient changes of biomarkers of thyroid function after syncopation and seizure.
Results of the study might contribute to an improved detection rate of thyrotoxicosis.
Transient allostatic responses of thyroid function have been described in critical illness. Own observations suggest similar reactive responses after syncopation and cerebral seizures. They are marked especially by increased concentration of serum thyrotropin (TSH), suggesting a type 2 allostatic response. However, changes of thyroid function after temporal loss of consciousness haven't been systematically evaluated up to now. Current diagnostic guidelines recommend primarily the determination of serum TSH concentration for screening of thyroid function, and the measurement of peripheral thyroid hormones (T4 and/or T3) is only recommended if TSH determination results in pathological values. This TSH reflex strategy may be misleading after short-term loss of consciousness.
This study aims at assessing the prevalence of allostatic responses of thyroid function after events of syncopation or seizure and at investigating the consecutive temporal development of biomarkers of thyroid function. An additional aim includes the diagnostic value of TSH determination, compared to measurement of free thyroid hormones, for thyroid dysfunction after syncopation or seizure.
Results of this study might contribute to an improved detection rate of thyrotoxicosis. In cases of medical emergencies and in-patient treatment interventions with a significant iodine load are common, including the application of iodinated radiocontrast agents and amiodarone. In this setting, undetected hyperthyroidism may lead to thyroid storm, which is associated with a high mortality.
881 studies on the registry are indexed under Seizures; 143 are open to participants now.
This study's planned enrollment of 350 is above the median of 150 across 235 observational studies indexed under Seizures.
Browse Seizures studies →Ruhr University of Bochum is the lead sponsor of 124 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Eligible are subjects addmitted for in-patient treatment after syncope or cerebral seicure
Exclusion Criteria:
Subjects admitted immediately after syncopation.
Diagnostic Test: Evalution of thyroid function
Subject admitted immediately after cerebarl seizure
Diagnostic Test: Evalution of thyroid function
Determination of TSH, free T4, free T3, SPINA-GT, SPINA-GD and Jostel's TSH index
Prevalence of allostatic responses of thyroid function after short-term loss of consciousness
Prevalence of increased TSH immediately after syncope or seizure
Time frame: 2 hours
Time series of thyroid function after short-term loss of consciousness
Temporal evolution of TSH and thyroid hormone concentration during three days after syncope or seicure
Time frame: 72 hours
Diagnostic value of TSH after short-term loss of consciousness
Sensitivity, specificitay and likelihood ratios of TSH compared to free T4 and free T3 after syncopation or seizure
Time frame: 72 hours
Plan to share: Undecided — Anonymised data may be shared upon request.
This study is status unknown, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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Ruhr University of Bochum