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CompletedNCT04842188Updated Jun 24, 2021

Furcation Treatment With L-PRF and aPDT

An interventional study of L-PRF with aPDT and L-PRF in Furcation Defects, sponsored by Kafrelsheikh University. Completed at 1 site in Egypt. Open to participants aged 32 Years to 48 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-06-24.

Sponsored by Kafrelsheikh University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 8 months after the study started (first participant enrolled Jul 2020, registered Apr 2021).
Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Randomized
Ages
32 Years to 48 Years
Sex
All
01

Study summary

To treat grade II periodontally diseased furcation areas Leukocyte-Platelet Rich Fibrin (L-PRF) combined with antimicrobial Photo-Dynamic Therapy (a-PDT) was used.

Read the detailed description

randomized, triple-blinded study (patient, clinician and biostatistician). Twenty-four patients with Grade II furcation involvement were recruited in this study.

Control group only received L-PRF, while study group used a combination of L-PRF and aPDT Attachment level, pocket depth, horizontal component and gingival recession, also radiographic Bone depth, width, height and volume were were recorded at baseline and postoperatively after 6 months

02

Conditions studied

  • Furcation Defects

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Keywords

  • platelet rich fibrin
  • photodynamic therapy
03

In context

Furcation Defects

42 studies on the registry are indexed under Furcation Defects; 13 are open to participants now.

This study's enrollment of 24 is below the median of 27 across 38 interventional studies indexed under Furcation Defects.

Browse Furcation Defects studies →

Lead sponsor

Kafrelsheikh University is the lead sponsor of 294 studies on the registry; 114 are open to participants now.

Of its 10 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
32 Years to 48 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Grade II furcation involvement
  • age range 18- 50 years
  • 3 mm or more vertical probing depth

Exclusion criteria

Exclusion Criteria:

  • systemic disease
  • abnormal clotting and bleeding
  • smokers,
  • root caries or restoration
  • Grade II mobility
  • periapical lesions
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
24 participants (actual)

Study arms

  • Active comparator
    L-PRF

    Leukocyte platelet rich fibrin as a sole graft material in class II furcation

    Procedure: L-PRF

  • Active comparator
    L-PRF with aPDT

    Leukocyte platelet rich fibrin combined with antibacterial photodynamic therapy in class II furcation

    Procedure: L-PRF with aPDT

Interventions

  • ProcedureL-PRF with aPDT

    surgical open flap debridement followed by L-PRF with aPDT

  • ProcedureL-PRF

    surgical open flap debridement followed by L-PRF alone

06

What researchers measure

Primary outcomes

  1. Clinical evaluation of Vertical clinical attachment level VCAL

    using periodontal probe in mm

    Time frame: 6 months

  2. clinical evaluation of vertical pocket depth VPD

    using periodontal probe in mm

    Time frame: 6 months

  3. clinical evaluation of furcation horizontal component FHC

    using periodontal probe in mm

    Time frame: 6 months

  4. clinical evaluation of gingival recession REC

    using periodontal probe in mm

    Time frame: 6 months

07

Study locations

1 site
  • faculty of dentistry, kafrelsheikh University
    Kafr Ash Shaykh, 214312, Egypt
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 24, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04842188
Responsible party
Walid Elamrousy (lecturer of oral medicine and periodontology, Kafrelsheikh University) — Principal investigator
First posted
Apr 13, 2021
Start date
Jul 28, 2020
Primary completion
Apr 12, 2021
Completion
Apr 30, 2021
Last update
Jun 24, 2021

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.

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