An interventional study of Minimally invasive non-surgical technique (MINST) and Minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection in Injectable Platelet-Rich Fibrin, Minimally Invasive and Non-Surgical Technique, sponsored by October 6 University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by October 6 University · Not applicable, Interventional, and Treatment
This study aims to compare the clinical and radiographic effectiveness of injectable platelet-rich fibrin (i-PRF) combined with minimally invasive non-surgical therapy (MINST) versus MINST alone in the management of class II furcation defects.
Periodontitis is a multifactorial inflammatory disease that occurs due to the challenge between the host response and specific periodontal pathogens, leading to a gradual destruction of the periodontal supporting tissues over time.
Different regenerative approaches have been proposed including guided tissue regeneration (GTR); bone grafts, bioactive agents such as enamel matrix derivative (EMD) and platelet concentrates.
Using the minimally invasive nonsurgical technique (MINST) implements magnification with microscope/loupes and delicate instruments, to perform the periodontal debridement with more effective root debridement and less soft tissue trauma. MINST significantly improve the visualization and root decontamination, and at the same time preserve the gingival margin and consequently improve the aesthetic results and tissue stability.
42 studies on the registry are indexed under Furcation Defects; 13 are open to participants now.
This study's planned enrollment of 30 is above the median of 27 across 38 interventional studies indexed under Furcation Defects.
Browse Furcation Defects studies →October 6 University is the lead sponsor of 148 studies on the registry; 34 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients will receive minimally invasive non-surgical technique (MINST) alone
Procedure: Minimally invasive non-surgical technique (MINST)
Patients will receive minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
Procedure: Minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
Patients will receive minimally invasive non-surgical technique (MINST) alone
Patients will receive minimally invasive non-surgical technique (MINST) + injectable platelet-rich fibrin (i-PRF) injection
Change in Radiographic Bone Fill at the Furcation Site
Radiographic bone fill at the furcation site will be assessed using cone-beam computed tomography (CBCT). The analysis will include measurement of the filled bone volume (FBV) at the furcation area using segmentation.
Time frame: 6 months after treatment
Change in Horizontal Clinical Attachment Level
Horizontal clinical attachment level will be assessed using periodontal probing at baseline and 6 months after treatment.
Time frame: 6 months after treatment
Change in Vertical Clinical Attachment Level
Vertical clinical attachment levels will be assessed using periodontal probing at baseline and 6 months after treatment.
Time frame: 6 months after treatment
Change in Probing Pocket Depth
Probing pocket depth (PPD) will be measured in millimeters from the gingival margin to the base of the periodontal sulcus at six sites per tooth using a UNC-15 periodontal probe. Measurements will be recorded at baseline and 6 months after treatment.
Time frame: 6 months after treatment
Change in Gingival Margin Location
The location of the gingival margin will be assessed by measuring the distance from the cemento-enamel junction (CEJ) to the gingival margin. Measurements will be recorded at baseline and 6 months after treatment.
Time frame: 6 months after treatment
Change in Plaque Index
Plaque index (PI) will be assessed to evaluate oral hygiene status by measuring dental plaque accumulation in areas adjacent to the gingival margin. Plaque index will be recorded at baseline and 6 months after treatment.
Time frame: 6 months after treatment
Change in Bleeding on Probing
Bleeding on probing (BoP) will be assessed by gently inserting a periodontal probe into the gingival sulcus at the base of the interdental papilla and recording the intensity of bleeding after a short delay. BoP will be assessed at baseline and 6 months after treatment.
Time frame: 6 months after treatment
Plan to share: Yes — The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Supporting information: Study protocol
Time frame: After the end of study for one year.
Access criteria: The data will be available upon a reasonable request from the corresponding author.
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.