An interventional study of High resolution manometry in Constipation, sponsored by University Hospital, Rouen. Recruiting at 3 sites in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-06.
Sponsored by University Hospital, Rouen · Not applicable, Interventional, and Diagnostic
Among 42 studies in Constipation with a site in France — 5 open to participants now, 5 under way, none of them phase 3. Constipation · France.
Among the 42 studies in Constipation with a site in France, this one is the 23rd largest by planned enrollment of the 34 interventional ones, is the only one that started in 2023, is one of 18 with no phase, and was the 35th registered.
1,046 studies on the registry are indexed under Constipation; 161 are open to participants now.
This study's planned enrollment of 76 is close to the median of 75 across 884 interventional studies indexed under Constipation.
Browse Constipation studies →5 of the 42 studies in Constipation with a site in France are open now, in 1 country. Each count lists the studies.
Of the 98 Constipation studies recruiting now, 32 (33%) set no upper age limit and 51 (52%) stop at 75 or younger; 16 take children under 18; 28 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →42 studies; the count open now beside each. This study's row is marked.
First in 1999; this study’s year is marked. 1 started in 2023.
Median enrollment 198 across the 34 interventional studies, 90 across the 8 observational. Of the 36 that completed or were terminated, 5 (14%) have results posted.
24 of 42 have an industry lead sponsor. The 10 most frequent:
University Hospital, Rouen is the lead sponsor of 418 studies on the registry; 106 are open to participants now.
University Hospital, Rouen has 5 studies filed under Constipation — fewer than ten, so there is no comparison to draw.
1 of the studies in Constipation with a site in France that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT04623359University Hospital, RouenUsefulness of High Resolution Manometry in Constipation | 2027-09 |
Among the 42 studies in Constipation with a site in France, from their registry updates:
Nothing recorded among them since 2026-09-25.
Constipation is a frequent symptom that is reported by more than 10% of the general population. In a few case, constipation is resistant to medical standard care, including osmotic and stimulant laxatives. The diagnosis of colonic inertia may be suspected in these patients although diagnostic criteria for colonic inertia may vary from one country to another. In France, the diagnosis of colonic inertia is based on manometric study of the colorectal contractile activity using manometric probe. Using conventional manometric catheters, severe alteration of the colorectal motility is found in a very small subset of patients, who may later benefit from surgery. The recent use of high resolution manometric probe allowed to map more precisely colorectal motility, but whether these new parameters are relevant remains to be assessed. The aim of this study is to assess the diagnostic performance of a new high resolution manometric probe by comparing healthy volunteers to patients suspected of colonic inertia.
For patient
Inclusion Criteria:
Exclusion Criteria:
Patient with constipation being either:
to the use of high resolution manometry insertion
For Healthy volunteers
Inclusion Criteria:
Exclusion Criteria:
Contra-indication to the use of high resolution manometry insertion
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Relapsed and refractory
Relapsed: the illness came back after treatment had worked. Refractory: it did not respond to treatment, or stopped responding while still on it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patient with constipation will have a high resolution manometry
Device: High resolution manometry
Healthy volunteers will have a high resolution manometry
Device: High resolution manometry
High resolution manometry
Frequency of isolated propagated colonic contractions
Number of colonic contractions during 24 hours
Time frame: 24 hours
Speed of isolated propagated colonic contractions
Average speed of colonic contractions during 24 hours
Time frame: 24 hours
Colonic transit time
Transit time will be measured during during the first 24 hours
Time frame: during the first 24 hours
Plan to share: No
No publications or documents are linked to this record.
Started Jan 2023 (actual). Primary completion is estimated for Sep 2027, 56 months after the start.
Of 243 non-industry interventional studies with no phase under Constipation, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 35. This study's planned 56 months is above that.
Counting every sponsor, half of 314 studies reached it within 14 months; a quarter within 6 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.