An interventional study of Eggshell membrane (ESM) and Placebo in Healthy, Inflammation and Aging, sponsored by University of Oslo. Completed at 1 site in Norway. Open to participants aged 70 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-01-21.
Sponsored by University of Oslo · Not applicable, Interventional, and Prevention
The aim of this project is to evaluate daily intake of eggshell membrane taken as supplement (capsule), will reduce markers of inflammation in older people.
3,439 studies on the registry are indexed under Inflammation; 629 are open to participants now.
This study's enrollment of 57 is above the median of 50 across 2,437 interventional studies indexed under Inflammation.
Browse Inflammation studies →University of Oslo is the lead sponsor of 176 studies on the registry; 23 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study will include home-dwelling men and women ≥ 70 years. All subjects have to be in a good enough condition to meet up at the Department of Nutrition, University of Oslo at two occasions during the study period.
Exclusion Criteria:
Participants will consume 2 capsules containing eggshell membrane(ESM) with breakfast every day in 4 weeks.
Other: Eggshell membrane (ESM)
Participants will consume 2 capsules with no bioactive substance (placebo) with breakfast every day in 4 weeks.
Other: Placebo
The intervention group will consume two capsules containing (in total) 500mg ESM with breakfast every day in 4 weeks.
The placebo group will consume two placebo capsules (Cellulose) with breakfast every day in 4 weeks
Change in plasma levels of inflammatory markers
concentration of C-reactive protein (CRP)
Time frame: Measured at baseline and after 4 weeks (end of study)
Change in plasma levels of inflammatory markers
concentration of TNFalpha
Time frame: Measured at baseline and after 4 weeks (end of study)
Changes in body composition - measured by Bioimpedance (BIA)
fat free mass (% and kg), fatt mass (% and in kg)
Time frame: Measured at baseline and after 4 weeks
Change in muscle strength
Measured by grip strength
Time frame: Measured at baseline and after 4 weeks
Changes in markers related to lipid metabolism
Blood concentrations of e.g. triglycerides, total-, LDL- and HDL- cholesterol, free fatty acids and lipoprotein subclasses
Time frame: Measured at baseline and after 4 weeks
Peripheral blood mononuclear cell (PBMC) gene expression
mRNA levels of of genes involved in lipid metabolism and inflammation
Time frame: Measured at baseline and after 4 weeks
Change in microbiota composition (optional)
Consenctration of faecal short-chain fatty acids
Time frame: Measured at baseline and after 4 weeks
Change in microbiota composition (optional)
bacteria type and diversity
Time frame: Measured at baseline and after 4 weeks
Changes in satiety hormones
e.g. concentration of serum ghrelin, amylin, leptin
Time frame: Measured at baseline and after 4 weeks
Changes in metabolome plasma profile
concentration of amino acids in blood
Time frame: Measured at baseline and after 4 weeks
Changes in metabolome plasma profile
concentration of low molecular molecules in blood
Time frame: Measured at baseline and after 4 weeks
Changes in body weight
Weight (kg) measured by digital scale
Time frame: Measured at baseline and after 4 weeks
Changes in body mass index (BMI)
Measured as body weight in kg/height in meter2 ( kg/m2)
Time frame: Measured at baseline and after 4 weeks
Changes in physical performance
Short Physical Performance Battery (SPPB) test (includes balance test, chair test (sit to stand) and walk test)
Time frame: Measured at baseline and after 4 weeks
This study is completed, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.
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University of Oslo