An interventional study of Transdiagnostic app intervention and Transdiagnostic mastery course in Major Depression Disorder and ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), sponsored by University of Oslo. Recruiting at 1 site in Norway. Open to participants aged 16 Years to 19 Years. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by University of Oslo · Not applicable, Interventional, and Prevention
Some adolescents experience periods of anxiety and/or depression, and some find that these periods return over time. The purpose of this study is to examine whether digital interventions-where individuals work systematically with their own thoughts and feelings during periods when they feel well-can help them maintain well-being for longer.
The study includes adolescents aged 16-19 who have previously experienced episodes of depression and/or anxiety to a degree that led them to seek help (e.g., from a school nurse, general practitioner, health clinic, or child and adolescent mental health service). Through a research app on their smartphones, participants complete tasks and answer questionnaires. The study is fully digital. Some participants meet with a therapist in digital group sessions, while others work independently with the digital content.
We will also examine the cost-benefit aspects of offering such interventions. If the study achieves its goals, digital interventions may eventually become a service offered to adolescents recovering from depression and anxiety.
84 studies on the registry are indexed under Phobic Disorders; 15 are open to participants now.
This study's planned enrollment of 495 is above the median of 66 across 69 interventional studies indexed under Phobic Disorders.
Browse Phobic Disorders studies →University of Oslo is the lead sponsor of 177 studies on the registry; 24 are open to participants now.
Compared within Phobic Disorders, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Anxiety Disorders. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
A transdiagnostic, self-guided CBT app: 1. Standardized self-assessment for mental health: 'Test your psychological immune system'. 2. Educational mini-series: A 30-minute, entertaining video series that teaches users to build resilience by addressing essential needs like sleep (psychological immune system), recognizing negative thought patterns (thought viruses), and developing healthier coping mechanisms (psychological vitamins). 3. Daily practice: Over 20 days, users receive a short, 1-2-minute video each morning. These videos provide practical tips, small experiments, or simple tasks designed to help users integrate healthier coping strategies into their daily lives.
Behavioral: Transdiagnostic app intervention
A transdiagnostic, mastery course for groups, delivered weekly in webinar format over three sessions. It includes videos and group discussions.
Behavioral: Transdiagnostic mastery course
Only assessment will be conducted.
A transdiagnostic, self-guided CBT app, called TankeVirus (literally translated Thought Viruses), consisting of three components: 1. Standardized self-assessment for mental health: 'Test your psychological immune system'. 2. Educational mini-series: A 30-minute, entertaining video series that teaches users to build resilience by addressing essential needs like sleep (psychological immune system), recognizing negative thought patterns (thought viruses), and developing healthier coping mechanisms (psychological vitamins). 3. Daily practice: Over 20 days, users receive a short, 1-2-minute video each morning. These videos provide practical tips, small experiments, or simple tasks designed to help users integrate healthier coping strategies into their daily lives.
Group-based webinar offering psychoeducation based on principles of CBT.
Relapse: Number of participants scoring above the diagnostic cut-off on the PHQ-9 modified for teens during the 12-month follow-up.
To use the PHQ-9 as a diagnostic aid for Major Depressive Disorder: * Questions 1 and/or 2 need to be endorsed as a "2" or "3" * Need five or more positive symptoms (positive is defined by a "2" or "3" in questions 1-8 and "1", "2", or "3" in question 9). * The functional impairment question (How difficult….) needs to be rated at least as "somewhat difficult."
Time frame: From enrollment to the end of follow-up at 12-months.
Time until relapse; reaching the diagnostic criteria of MDD according to PHQ-9 modified for teens
Number of days until the diagnostic criteria of MDD as assessed PHQ-9 modified for teens has been reached. \- Questions 1 and/or 2 need to be endorsed as a "2" or "3" * Need five or more positive symptoms (positive is defined by a "2" or "3" in questions 1-8 and by a "1", "2", or "3" in question 9). * The functional impairment question (How difficult….) needs to be rated at least as "somewhat difficult."
Time frame: From enrollment to 12-months follow-up
Repetitive negative thinking (RNT-10)
Assess transdiagnostic repetitive negative thinking
Time frame: At enrollment, and at 3, 6 and 12 months follow-up
Somatic complaints (SSS8)
Somatic complaints based on sum score of all items
Time frame: At enrollment, and at 3, 6, and 12-months follow-up.
EPOCH Measure of Adolescent Well-Being
A 20-item validated questionnaire (4 items per domain; Engagement, Perseverance, Optimism, Connectedness, Happiness) on a 1-5 Likert scale (1=Almost Never, 5=Almost Always) resulting in domain scores, reflecting strengths in these positive psychological areas crucial for youth well-being.
Time frame: At baseline, 3, 6 and 12-months follow-up.
Health related quality of life
EQ-5D-5L will be used to assess five domains of patient reported outcomes and for economic evaluation of the interventions.
Time frame: At baseline, 3, 6 and 12-months follow-up.
Health related quality of life - Visual Analog Scale
EQ VAS will be used to assess patient reported outcomes for self-rated health and for economic evaluation of the interventions.
Time frame: At baseline, 3, 6 and 12-months follow-up.
Client satisfaction questionnaires (CSQ-I)
The 8-item questionnaire assesses how satisfied the participants are with the interventions, only administrated to those who are in the interventional arms.
Time frame: At 3 months follow-up.
Plan to share: Yes — The dataset underlying the results will be shared together with publications.
Started Aug 2026 (actual). Primary completion is estimated for Feb 2028, 17 months after the start.
Of 28 interventional studies with no phase under Phobic Disorders, half reached primary completion within 31 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 44. This study's planned 17 months is below that.
Since we started tracking on Sep 25, 2026, the dates moved once, on Nov 5, 2026: start Apr 2026 → Aug 2026, primary completion Jun 2027 → Feb 2028 and completion Jun 2027 → Feb 2028.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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