An observational study in Complex Regional Pain Syndromes and Chronic Pain, sponsored by Uppsala University. Completed at 1 site in Sweden. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2024-02-28.
Sponsored by Uppsala University · Observational
Complex regional pain syndrome, CRPS, is an uncommon but often very disabling chronic pain syndrome characterized by, beside pain: sensory disturbances, peripheral autonomic changes and inflammatory features. The diagnosis is subdivided in CRPS type 1 where no nerve injury has been identified, and CRPS type 2 when a major nerve injury has been verified.
A combination of exposure in vivo, a form of behaviour therapy where the patient is gradually confronted with avoided movements and activities, and interventions directly targeting a hypothesized cortical reorganisation is an interesting novel approach for treating CRPS.
The present study consists of (1) a qualitative interview study with 10-15 subjects that has received this form of treatment, in order to better understand their experience and effects of the treatment, and (2) a case series with long-term follow-up of 3-5 subjects that received the treatment för 5-8 years ago, in order to study the long term effects of the treatment.
Subjects with CRPS 1 or 2, diagnosed according to the Budapest criteria that has received in-patient treatment at Uppsala University Hospital, comprised of graded exposure therapy in vivo, in combination with methods targeting cortical reorganisation.
Exclusion Criteria:
Behavioral: Multimodal rehabilitation
A combination of exposure in vivo and interventions directly targeting the cortical reorganization for treating CRPS.
Diagnosis
Whether the subject still fulfill diagnostic criteria for CRPS
Time frame: 1 day
Subjective experience
A qualitative interview targeting the subjects own experience of the treatment and its effect
Time frame: 1 day
Level of pain
Subjective level of pain on a Likert-scale 0-10 (NRS)
Time frame: 1 day
Subjective experience of quality of life
Quality of life, measured with the RAND-36 (0-100, higher scores mean a better outcome)
Time frame: 1 day
Global impression of change
Global impression of change measured with a single question (0-6, higher scores mean a better outcome)
Time frame: 1 day
Acceptance of pain
Measured with the Chronic Pain Acceptance Questionnaire, CPAQ (0-156, higher scores mean a better outcome)
Time frame: 1 day (0-156, higher scores mean a better outcome)
Fear of pain
Measured with the Tampa Scale of Kinesiophobia, TSK (0-52, lower scores mean a better outcome)
Time frame: 1 day (0-52, lower scores mean a better outcome)
Pain catastrophizing
Measured with Pain Catastrophizing Scale, PCS (0-52, lower scores mean a better outcome)
Time frame: 1 day (0-52, lower scores mean a better outcome)
Avoidance of activities
Measured with the Photograph Series of Daily Activities, PHODA (0-100, lower scores mean a better outcome)
Time frame: 1 day (0-100, lower scores mean a better outcome)
Neglect of the affected limb
Measured with a five item questionnaire (0-36, lower scores mean a better outcome)
Time frame: 1 day (0-36, lower scores mean a better outcome)
Subjective experience of quality of life 2
EuroQol 5D, EQ-5D (0-15, higher scores means a better outcome)
Time frame: 1 day
Subjective experience of quality of life 3
Life Satisfaction Questionnaire, LiSat 11 (11-66, higher scores means a better outcome)
Time frame: 1 day
Plan to share: Undecided
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This study is completed, as verified in Feb 2024. You cannot join it, but the record below documents what was studied.
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Complex Regional Pain Syndromes→
Uppsala University