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Status unknownNCT04544579Updated Sep 10, 2020

Endovascular Graft Anchoring Different Regions of Ascending Aorta in the Treatment of Ascending Aortic Dissection

An observational study in Ascending Aortic Dissection, sponsored by Chinese Medical Association. Status unknown. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2020-09-10.

Sponsored by Chinese Medical Association · Observational

The sponsor has not verified this record recently (last verified Sep 2020), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
18 Years to 100 Years
Sex
All
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Study summary

Aortic dissection is a deadly and dangerous disease. About 28% of patients with ascending aortic dissection can't tolerate open surgical trauma caused by thoracotomy and cardiopulmonary bypass, and the prognosis is poor. Minimally invasive endovascular treatment has been applied in the treatment of descending aortic dissection. However, due to the special anatomical structure and high speed /pressure blood flow, the treatment of ascending aorta dissection has become an international difficulty.

Read the detailed description

This study was designed combination of retrospective and prospective methods, and focused on distal false lumen Aneurysmal Expansion of Aortic Dissection (DAEAD) . To formulate clinical data for the risk assessment of DAEAD, and best intracavitary treatment or long-term efficacy evaluation, we combined the results of genetic testing, evaluating the missense mutation, computer simulation of blood flow dynamics analysis, and clinical imaging analysis.

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Conditions studied

  • Ascending Aortic Dissection

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03

In context

Aortic Dissection

386 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.

This study's planned enrollment of 200 is close to the median of 182 across 179 observational studies indexed under Aortic Dissection.

Browse Aortic Dissection studies →

Lead sponsor

Chinese Medical Association is the lead sponsor of 39 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

This clinical trial included a prospective study of patients admitted to the hospital with aortic dissection between October 2020 and September 2023 who were treated with an endoluminal graft after exclusion of surgical contraindications.

Inclusion criteria

  • Aortic dissection diagnosed by CTA;
  • With indications for endovascular treatment
  • The luminal graft anchor is required to be located in the ascending aorta.

Exclusion criteria

Exclusion Criteria:

  • Import difficult, such as external iliac artery diameter is less than 6 mm bilateral iliac, artery stenosis distortions;
  • Patients with severe comorbidities, such as severe myocardial insufficient blood supply, heart failure, arrhythmia, severe renal dysfunction, and severe blood coagulation dysfunction;
  • Patients with malignant tumor, or other serious illness, life expectancy of less than 1 year;
  • Puncture local infection and high fever;⑤ within 1 month of the large area;
  • Contrast media in patients with cerebrovascular accident or digestive tract hemorrhage patients with allergies;
  • Aortic ulcer or aortic wall hematoma and other atypical dissection.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Patient registry
No

Groups and cohorts

  • Ascending aortic dissection patients

    Ascending aortic dissection patients

    Device: Stent grafts anchored in different areas

Interventions

  • DeviceStent grafts anchored in different areas

    Endovascular repair of ascending aortic dissection patients with stent grafts anchored in different areas

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What researchers measure

Primary outcomes

  1. success of operation

    The operation was completed successfully without complications.

    Time frame: before December 2022

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Pei Y, Zhu H, Xiao Y, Zhou J, Jing Z. The Mini-Cross Prefenestration for Endovascular Repair of Aortic Arch Pathologies. Front Cardiovasc Med. 2022 Jan 11;8:745871. doi: 10.3389/fcvm.2021.745871. eCollection 2021. PubMed 35087876 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 10, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04544579
Lead sponsor
Chinese Medical Association
Collaborators
Changhai Hospital
Responsible party
Zaiping Jing (Professor, Chinese Medical Association) — Principal investigator
First posted
Sep 10, 2020
Start date
Oct 1, 2020 (estimated)
Primary completion
Sep 1, 2022 (estimated)
Completion
Sep 30, 2022 (estimated)
Last update
Sep 10, 2020

Study contacts

Zaiping Jing, professor
Contact
xueguanky@163.com
02131161670
Zaiping Jing, Professor
principal investigator · Vascular surgery, Changhai Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.

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