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Active, not recruitingNCT04481087Updated Sep 29, 2025

Clinical Comparison of Different Adhesives in NCCLs

An interventional study of Clearfil Universal Bond Quick and Clearfil Universal Bond Quick in Tooth Wear, sponsored by Hacettepe University. Active, not recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-29.

Sponsored by Hacettepe University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 2 years 5 months after the study started (first participant enrolled Feb 2018, registered Jul 2020).
Phase
Not applicable
Study type
Interventional
Enrollment
34
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The aim of this randomized, controlled, prospective clinical trial is to evaluate the performances of a universal adhesive in three different application modes, a self-etch adhesive and an etch\&rinse adhesive in restoration of non-caries cervical lesions. Thirty-four patients will receive restorations. Lesions will be divided into 5 groups according to adhesive systems and application modes: CU-SE: Clearfil Universal Bond Quick in self-etch mode, CU-SLE: Clearfil Universal Bond Quick in selective etch mode, CU-ER: Clearfil Universal Bond Quick in etch\&rinse mode, CSE: Clearfil SE Bond, TB: Tetric N-Bond. Restorations (Tetric N-Ceram composite) will be scored with regard to retention, marginal discoloration, marginal adaptation, recurrent caries and post operative sensitivity using modified USPHS criteria after 48 months. Two examiners who is not involved in the placement of restorations will conduct the evaluations. Descriptive statistics will be performed using Chi-square tests.

02

Conditions studied

  • Tooth Wear

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03

In context

Tooth Wear

57 studies on the registry are indexed under Tooth Wear; 10 are open to participants now.

This study's enrollment of 34 is below the median of 49 across 37 interventional studies indexed under Tooth Wear.

Browse Tooth Wear studies →

Lead sponsor

Hacettepe University is the lead sponsor of 983 studies on the registry; 212 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • being 18 years or older,
  • having no medical or behavioral problems preventing then from attending review visits,
  • having at least 5 tooth with NCCLs
  • having antagonist teeth

Exclusion criteria

Exclusion Criteria:

  • poor gingival health,
  • uncontrolled, rampant caries,
  • bruxism,
  • removable partial dentures,
  • xerostomia
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
34 participants (actual)

Study arms

  • Experimental
    Clearfil Universal Bond Quick, self-etch mode (CU-SE)

    Device: Clearfil Universal Bond Quick

  • Experimental
    Clearfil Universal Bond Quick, selective etch mode (CU-SLE)

    Device: Clearfil Universal Bond Quick

  • Experimental
    Clearfil Universal Bond Quick, etch&rinse mode (CU-ER)

    Device: Clearfil Universal Bond Quick

  • Experimental
    Clearfil SE Bond (CSE)

    Device: Clearfil SE Bond

  • Experimental
    Tetric N-Bond (TB)

    Device: Tetric N-Bond

Interventions

  • DeviceClearfil Universal Bond Quick

    Adhesive systems

  • DeviceClearfil Universal Bond Quick

    Adhesive systems

  • DeviceClearfil Universal Bond Quick

    Adhesive systems

  • DeviceClearfil SE Bond

    Adhesive systems

  • DeviceTetric N-Bond

    Adhesive systems

06

What researchers measure

Primary outcomes

  1. Clinical performances of different adhesives

    Two year examinations according to USPHS criteria

    Time frame: two years

07

Study locations

1 site
  • Hacettepe University
    Ankara, Turkey (Türkiye)
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 29, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04481087
Lead sponsor
Hacettepe University
Responsible party
Dr. Fatma Dilşad Öz (Associate Professor, Hacettepe University) — Principal investigator
First posted
Jul 22, 2020
Start date
Feb 10, 2018
Primary completion
May 10, 2018
Completion
Jun 10, 2026 (estimated)
Last update
Sep 29, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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