ClinicalTrials.gg
RecruitingNCT04433455Updated Sep 23, 2026

Influencing Factors of Cerebrovascular Disease and Cognition in Hemodialysis Patients

An observational study in Hemodialysis, Cognitive Impairment and Cerebrovascular Disorders, sponsored by Huashan Hospital. Recruiting at 1 site in China. Open to participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2026-09-23.

Sponsored by Huashan Hospital · Observational

From the registry’s dates

  • Started Jun 2020; still recruiting 6 years 5 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
20
Ages
50 Years to 85 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 309 studies in Cognitive Dysfunction with a site in China — 143 open to participants now, 155 under way, 8 of them phase 3. Cognitive Dysfunction · China.

Planned enrollment
116th of 119
20 · median 300
Started
2020
with 23 others
Observational
119 of 309
64 open now
Primary completion
2026-12
later than 72 of 154 live
Registered
90th of 309
by date

Among the 309 studies in Cognitive Dysfunction with a site in China, this one is the 116th largest by planned enrollment of the 119 observational ones that give a count, is one of 24 that started in 2020, is one of 119 observational ones, reaches primary completion later than 72 of the 154 other live ones, and was the 90th registered.

Cognitive Dysfunction

3,875 studies on the registry are indexed under Cognitive Dysfunction; 1,121 are open to participants now.

Browse Cognitive Dysfunction studies →

Open to participants now

143 of the 309 studies in Cognitive Dysfunction with a site in China are open now. Recruiting first, the newest first:

138 more — sign in →

All 143 open studies →

A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →

Who these studies take

Of the 751 Cognitive Dysfunction studies recruiting now, 363 (48%) set no upper age limit and 143 (19%) stop at 75 or younger; 46 take children under 18; 259 take healthy volunteers.

This study: 50 Years to 85 Years · all sexes · no healthy volunteers.

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02

Study summary

In this observational study, the investigators evaluate the influencing factors of cerebrovascular disease and cognition in hemodialysis patients.

03

Conditions studied

  • Hemodialysis
  • Cognitive Impairment
  • Cerebrovascular Disorders
04

Who can participate

Ages eligible
50 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

maintenance hemodialysis patients

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. maintenance hemodialysis patients who are younger than 85 years old and older than 50 years old, regardless of gender
  2. dialysis vintage is greater than 3 months;

Exclusion criteria

Exclusion Criteria:

  1. Those with severe infection and anemia ( \<60g / L);
  2. Those with severe mental illness, metabolic diseases and immune system diseases;
  3. Patients with abnormal liver function
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Hemoglobin (Hb)

The protein in red blood cells that carries oxygen. A low level is anaemia, which can cause tiredness and breathlessness. Measured in g/dL or g/L (9 g/dL is 90 g/L).

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
20 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. cerebrovascular disease

    Magnetic resonance images will be used to determine the severity of white matter hyperintensity, using the Scheltens scale. Score 2 or more is abnormal.

    Time frame: 5 years

Secondary outcomes

  1. changes in cognitive function

    The Mini-Mental State Examination (MMSE) will be used to assess the changes in cognitive function.The MMSE has a maximum score of 30 points. The scores are generally grouped as follows: 25-30 points: normal cognition 21-24 points: mild dementia 10-20 points: moderate dementia 9 points or lower: severe dementiaThe Mini-Mental State Examination (MMSE) will be used to assess the changes in cognitive function.The MMSE has a maximum score of 30 points. The scores are generally grouped as follows: 25-30 points: normal cognition 21-24 points: mild dementia 10-20 points: moderate dementia 9 points or lower: severe dementia

    Time frame: 5 years

07

Study locations

1 of 1 sites recruiting
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Jun 2020 (actual). Primary completion is estimated for Dec 2026, 78 months after the start.

Of 504 non-industry observational studies under Cognitive Dysfunction, half reached primary completion within 49 months of starting (the median), counting those still running; a quarter within 22 and three quarters within 118. This study's planned 78 months is above that.

Counting every sponsor, half of 543 studies reached it within 47 months; a quarter within 21 and three quarters within 118.

How these figures are worked out, and which studies are left out of them.

Registered
May 19, 2020
First posted
Jun 16, 2020
StartActual
Jun 1, 2020
Primary completionEst.
Dec 31, 2026
CompletionEst.
Dec 31, 2026
Last update
Sep 23, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 23, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04433455
Lead sponsor
Huashan Hospital
Responsible party
Chen Jing (Professor, Huashan Hospital) — Principal investigator
First posted
Jun 16, 2020
Start date
Jun 1, 2020
Primary completion
Dec 31, 2026 (estimated)
Completion
Dec 31, 2026 (estimated)
Last update
Sep 23, 2026

Study contacts

Jing Chen
Contact
chenjing1998@fudan.edu.cn
862152889325
Jing Chen
principal investigator · Huashan Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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