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RecruitingNCT07603102Updated May 22, 2026

Mindfulness With Dual-Task Training in Post-Stroke Mild Cognitive Impairment

An interventional study of mindfulness and Dual-Task Training in Stroke and Mild Cognitive Impairment (MCI), sponsored by Nanjing Mingzhou Rehabilitation Hospital. Recruiting at 1 site in China. Open to participants aged 55 Years and older. Per ClinicalTrials.gov, last updated 2026-05-22.

Sponsored by Nanjing Mingzhou Rehabilitation Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started May 2026; still recruiting 5 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
55 Years and older
Sex
All
01

Study summary

This study aims to investigate whether a combined intervention of mindfulness and dual-task training can improve cognitive function and physical performance in individuals with mild cognitive impairment after stroke.

02

Conditions studied

  • Stroke
  • Mild Cognitive Impairment (MCI)
03

In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's planned enrollment of 60 is above the median of 50 across 5,369 interventional studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Nanjing Mingzhou Rehabilitation Hospital is the lead sponsor of 5 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
55 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Diagnosis of stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI).
  • Time since stroke onset ≥3 months and medically stable.
  • Presence of mild cognitive impairment after stroke, defined by a Montreal - - Montreal Cognitive Assessment (MoCA) score \< 26.
  • Mini-Mental State Examination (MMSE) score ≥ 24.
  • Ability to walk independently with or without an assistive device for at least 10 meters.
  • Stable medication regimen for at least 4 weeks prior to enrollment.
  • Ability to understand study instructions and provide written informed consent.

Exclusion criteria

Exclusion Criteria:

  • Severe aphasia, visual impairment, hearing impairment, or communication disorders that interfere with assessment or training participation.
  • Severe depression or other major psychiatric disorders.
  • Other neurological diseases affecting cognition or movement (e.g., Parkinson's disease, multiple sclerosis, traumatic brain injury).
  • Severe musculoskeletal, cardiovascular, or systemic diseases that contraindicate exercise participation.
  • Participation in other structured cognitive or rehabilitation intervention programs within the past 3 months.
  • Unstable medical condition or recurrent stroke during the study period.
  • Inability to safely complete the training protocol as determined by the study investigators.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
60 participants (estimated)

Study arms

  • Experimental
    MDT group

    Mindfulness + Dual-Task Training

    Other: mindfulness · Device: Dual-Task Training

  • Experimental
    DT group

    Dual-Task Training + Health Education

    Device: Dual-Task Training · Other: Health education

  • Experimental
    AT group

    Aerobic Training + Health Education

    Device: Aerobic Training · Other: Health education

Interventions

  • Othermindfulness

    Guided by a professional mindfulness instructor, participants engage in mindfulness meditation to enhance attention, emotional regulation, and cognitive readiness. The training includes breath awareness, body scan, and present-moment awareness, delivered through guided meditation.Other Name:

  • DeviceDual-Task Training

    Dual-task training is a rehabilitation approach that targets cognitive-motor integration by requiring participants to perform a motor task and a cognitive task simultaneously. Examples include walking while performing mental calculations, memory tasks, or reaction-based exercises. The training is progressively adjusted by increasing task difficulty and cognitive load to improve attention allocation, executive function, and dual-task performance in daily activities.

  • DeviceAerobic Training

    Dual-task training is a rehabilitation approach that targets cognitive-motor integration by requiring participants to perform a motor task and a cognitive task simultaneously. Examples include walking while performing mental calculations, memory tasks, or reaction-based exercises. The training is progressively adjusted by increasing task difficulty and cognitive load to improve attention allocation, executive function, and dual-task performance in daily activities.

  • OtherHealth education

    Health education is a non-exercise control intervention designed to provide participants with knowledge related to post-stroke health management. Topics include stroke recovery, healthy lifestyle behaviors, nutrition, medication adherence, daily activity management, and psychological well-being. The intervention is delivered through structured educational sessions or instructional materials and does not include active physical or cognitive training components.

06

What researchers measure

Primary outcomes

  1. Montreal Cognitive Assessment (MoCA)

    The Montreal Cognitive Assessment (MoCA) is a widely used neuropsychological tool for detecting mild cognitive impairment (MCI). It assesses multiple cognitive domains, including attention, executive function, memory, language, visuospatial ability, abstraction, calculation, and orientation. The total score is 30 points, with higher scores indicating better cognitive function.

    Time frame: From enrollment to the end of treatment at 4 weeks

07

Study locations

1 of 1 sites recruiting
  • Nanjing Mingzhou Rehabilitation Hospital
    Nanjing, China
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 22, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07603102
Lead sponsor
Nanjing Mingzhou Rehabilitation Hospital
Responsible party
Jingzhi Zhang (supervisor technician, Nanjing Mingzhou Rehabilitation Hospital) — Principal investigator
First posted
May 22, 2026
Start date
May 1, 2026
Primary completion
Nov 2026 (estimated)
Completion
Nov 2026 (estimated)
Last update
May 22, 2026

Study contacts

Jingzhi Zhang
Contact
170787717@qq.com
+86-16677137704

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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