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Status unknownNCT04321733Updated Mar 25, 2020

Bacteriological Study of Acute Follicular Tonsillitis

An observational study in Acute Follicular Tonsillitis, sponsored by Assiut University. Status unknown. Open to participants aged 5 Years to 60 Years. Per ClinicalTrials.gov, last updated 2020-03-25.

Sponsored by Assiut University · Observational

The sponsor has not verified this record recently (last verified Mar 2020), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
66
Ages
5 Years to 60 Years
Sex
All
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Study summary

The objective of the study is to answer the following questions :-

  1. Is there an actual failure rate in tonsillitis treatment with amoxicillin clavulanate ? If yes,
  2. What is (are) the possible reason(s) to explain it in our locality ?
Read the detailed description

Tonsillitis is one of the most common diseases in the throat that occurs in the younger age group .

The predominant bacteria causing tonsillitis are group A b-haemolytic streptococci (GABHS), which are highly susceptible to the penicillin group of antibiotics.

It has been reported in the literature that the rate of penicillin failure has consistently increased from about 7% in the 1950s to almost 40% in the 2000s.

Authors propose many reasons to explain such failure rates e.g. the coexistence of oropharyngeal beta-lactamase producing bacteria .

Although there were no documented reports, it was observed that there are rising reports of failure in treatment of acute follicular tonsillitis by amoxicillin clavulanate.

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Conditions studied

  • Acute Follicular Tonsillitis

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03

In context

Tonsillitis

103 studies on the registry are indexed under Tonsillitis; 12 are open to participants now.

This study's planned enrollment of 66 is below the median of 100 across 15 observational studies indexed under Tonsillitis.

Browse Tonsillitis studies →

Lead sponsor

Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.

Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
5 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with acute follicular tonsillitis

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

patients with acute follicular tonsillitis neither younger than five years nor older than 60 years old.

Exclusion criteria

Exclusion Criteria:

  1. Other causes of tonsillitis that do not cause suppuration .
  2. Age below five , and above 60 years .
  3. Patients who received antibiotic one week before presentation .
  4. Immune compromised patients .
  5. Patients with quinsy.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
66 participants (estimated)
Patient registry
No

Interventions

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What researchers measure

Primary outcomes

  1. The sensitivity of the isolated organism to amoxicillin clavulanate according to culture and sensitivity test

    throat swabs that will be taken from the tonsillar exudate, placed in sterile bottles and brought to the laboratory for Bacteriological culture of the organism and Antibiotic sensitivity tests will be done for the isolated organism(s).

    Time frame: Baseline

07

Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Brook I. Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo-tonsillitis. Int J Pediatr Otorhinolaryngol. 2007 Oct;71(10):1501-8. doi: 10.1016/j.ijporl.2007.06.006. Epub 2007 Jul 17. PubMed 17644191 ↗
  • Casey JR, Pichichero ME. The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):39S-45S. doi: 10.1016/j.diagmicrobio.2006.12.020. Epub 2007 Feb 9. PubMed 17292576 ↗
  • Sela S, Barzilai A. Why do we fail with penicillin in the treatment of group A streptococcus infections? Ann Med. 1999 Oct;31(5):303-7. doi: 10.3109/07853899908995895. PubMed 10574501 ↗

Related links

Individual participant data

Plan to share: Undecided

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 25, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04321733
Lead sponsor
Assiut University
Responsible party
Mena Wahby Dous Hana (Principal investigator, Assiut University) — Principal investigator
First posted
Mar 25, 2020
Start date
Apr 2020 (estimated)
Primary completion
Apr 2021 (estimated)
Completion
Oct 2021 (estimated)
Last update
Mar 25, 2020

Study contacts

Mena W Dous, Principal investigator
Contact
Dr_manoon@hotmail.com
+201277170022
Alaa K Abd El Haleem, Professor of Otolaryngology
Contact
+201005534200

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.

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