An observational study in Pre-eclampsia, sponsored by Far Eastern Memorial Hospital. Recruiting at 1 site in Taiwan. Open to female participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2023-03-29.
Sponsored by Far Eastern Memorial Hospital · Observational
To evaluate the clinical effectiveness of this screening program in preventing pre-eclampsia.
The incidence of pre-eclampsia is about 2-8%, it is a leading cause of maternal and perinatal mortality and morbidity. Both ACOG (American Congress of Obstetricians and Gynecologists) and NICE (National Institute for Health and Clinical Excellence) guideline advocate the use of traditional screening method, which uses demographic characters and medical history to identify high risk women. This method detects only 35-40% of pre-eclampsia women. Study has shown that combination of maternal factors and biomarkers (uterine artery pulsatility index, placenta growth factor, PlGF; pregnancy associated plasma protein-A, PAPP-A) improves the detection rate.
In Taiwan, the prevalence of pre-eclampsia is about 1.21%. The incidence of pre-eclampsia is correlated with maternal age, with a relative risk of 5.13-fold in women aged 40 and above. Marrying late predisposes these women at high risk of developing pre-eclampsia. Our institution will be implementing first-trimester screening program starting from April 2019, this study aims to evaluate the clinical effectiveness of this screening program in preventing pre-eclampsia.
women with with singleton pregnancy
Exclusion Criteria:
This screening program included the use of ultrasound, biomarkers and maternal factors in calculating the risk of developing preeclampsia.
The sensitivity and specificity of this screening program to detect preeclampsia
Time frame: 5 years
Plan to share: No
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Far Eastern Memorial Hospital