An interventional study of Routine oral cleaning and professional oral care group in Pneumonia, sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital. Completed. Open to participants aged 51 Years to 102 Years. Per ClinicalTrials.gov, last updated 2019-03-14.
Sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital · Not applicable, Interventional, and Supportive care
The correlation between improvement in oral health, reduction in oral bacterial concentration, and status of pneumonia hospitalization remains unclear. To determine the effects of professional oral care intervention on the index of oral health, salivary and sputum bacterial concentrations, and pneumonia hospitalization status of nursing home residents using a quasi-experimental study. Two nursing homes were on demand selected as the intervention and control groups; in the intervention group, weekly professional oral care was administered in addition to regular oral care by trained dental hygienists. Demographic data and oral health status were analyzed. Total salivary and sputum bacterial concentrations were determined using real-time polymerase chain reaction.
2,044 studies on the registry are indexed under Pneumonia; 283 are open to participants now.
This study's enrollment of 220 is above the median of 106 across 1,247 interventional studies indexed under Pneumonia.
Browse Pneumonia studies →Kaohsiung Medical University Chung-Ho Memorial Hospital is the lead sponsor of 281 studies on the registry; 57 are open to participants now.
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Exclusion Criteria:
The subjects in "Routine oral cleaning and professional oral care group" were received about routine oral cleaning and professional oral care.
Other: Routine oral cleaning and professional oral care group
The subjects in "Routine oral cleaning group" were received only routine oral cleaning, just maintain daily condition.
Besides routine oral cleaning was conducted by caregivers, professional oral care intervention was conducted by dental hygienists, and it included muscle massage, oral cleaning, and oral health education once a week.
Pneumonia hospitalization status
Hospitalization prevalence and days of each hospitalization due to pneumonia were collected from medical records by questionnaire.
Time frame: 2 hours
Bacterial concentrations
Total salivary and sputum bacterial concentrations were determined using real-time polymerase chain reaction. Staphylococcus aureus (strain ID: ATCC 29213) was used to create the standard growth curve of bacteria. After overnight culture, the samples were prepared by 5-fold serial dilution with normal saline and plating in a Petri dish to produce 2.5×103 to 3.9×107 CFU/mL of bacteria. Genomic DNA of bacteria was extracted from 1 mL of each bacterial serial solution using the modified standard method, which followed three basic steps: lysis, precipitation, and purification. The DNA extracts were resuspended in 20 µL of distilled water and stored at -80°C until real-time polymerase chain reaction (RT-PCR) amplification. The standard curve of bacterial concentration was generated by the bacterial 16S rRNA gene using a serial dilution of Staphylococcus aureus genomic DNA and StepOnePlus Real-Time PCR System (Applied Biosystems).
Time frame: 3 hours
Oral health examinations
Oral health examinations were conducted by two trained dentists, and data on plaque, gingival, and tongue coating indexes were collected by oral examination tables.
Time frame: 3 hours
Demographic data
Demographic data included gender, age groups, conscious, educational level, and nutritional route, which were collected by questionnaire.
Time frame: 1 hour
No study locations are listed for this record.
Plan to share: Yes — De-identified IPD for outcome measures will be made available.
Supporting information: Study protocol
This study is completed, as verified in Mar 2019. You cannot join it, but the record below documents what was studied.
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Kaohsiung Medical University Chung-Ho Memorial Hospital