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Enrolling by invitationNCT03243448Updated Aug 10, 2026

Skin Sympathetic Nerve Activity and Sympathetic Tone

An observational study in Nerve; Disorder, Sympathetic and Healthy, sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital. Enrolling by invitation. Open to participants aged 20 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-10.

Sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
1,000
Ages
20 Years to 85 Years
Sex
All
01

Study summary

There are many sympathetic hyperactivity diseases in the investigators' clinical practice. However, the conventional method to measure the sympathetic nerve activity had many limitations such as clinical application, data interpretation and even therapeutic manipulation. Therefore the investigators would like to develop a non-invasive method to record the sympathetic nerve activity in the investigators' study that can help gathering the sympathetic nerve activity easily in the investigators' daily clinical situation. By the determination of sympathetic nerve activity status, the health caregiver can understand the disease more.

02

Conditions studied

  • Nerve; Disorder, Sympathetic
  • Healthy
03

Who can participate

Ages eligible
20 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

The subjects who are eligible to the inclusion criteria and admitted to the investigators' ward, visited the investigators' outpatient clinic or health checkup center will be enrolled in the investigators' study.

Inclusion criteria

  • Sympathetic hyperactivity diseases included: hypertension, heart failure atherosclerotic diseases, arrhythmias, cardiomyopathy, pulmonary hypertension, chronic obstructive pulmonary disease, sleep apnea, pulmonary embolism, hepatitis, liver cirrhosis, hepatopulmonary syndrome, hepatorenal syndrome, renal failure, nephritis, irritable bowel syndrome.
  • Healthy Volunteers

Exclusion criteria

Exclusion Criteria:

  • Pregnant
04

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
1,000 participants (estimated)
Target follow-up
1 Year
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • The general public

    people between 20-85 years old, without sympathetic hyperactivity disease

  • Sympathetic hyperactivity diseases

    Sympathetic hyperactivity diseases included: hypertension, heart failure atherosclerotic diseases, arrhythmias, cardiomyopathy, pulmonary hypertension, chronic obstructive pulmonary disease, sleep apnea, pulmonary embolism, hepatitis, liver cirrhosis, hepatopulmonary syndrome, hepatorenal syndrome, renal failure, nephritis, irritable bowel syndrome.

05

What researchers measure

Primary outcomes

  1. Skin Sympathetic Nerve Activity

    The Sympathetic Nerve Activity Recording from the skin of the subjects in the day time.

    Time frame: 12 hours

Secondary outcomes

  1. ventricular arrhythmia

    The electrocardiogram recording from the telemetry.

    Time frame: 24 to 72 hours

  2. Mortality

    The mortality will be accessed by the chart review and telephone access

    Time frame: 1 to 12 months

  3. Morbidity

    The morbidity will be accessed by the chart review and telephone access

    Time frame: 1 to 12 months

06

Study locations

No study locations are listed for this record.

07

References and documents

Publications

  • Shen MJ, Coffey AC, Straka S, Adams DE, Wagner DB, Kovacs RJ, Clark M, Shen C, Chen LS, Everett TH 4th, Lin SF, Chen PS. Simultaneous recordings of intrinsic cardiac nerve activity and skin sympathetic nerve activity from human patients during the postoperative period. Heart Rhythm. 2017 Nov;14(11):1587-1593. doi: 10.1016/j.hrthm.2017.06.030. Epub 2017 Jun 23. PubMed 28648667 ↗
  • Everett TH 4th, Doytchinova A, Cha YM, Chen PS. Recording sympathetic nerve activity from the skin. Trends Cardiovasc Med. 2017 Oct;27(7):463-472. doi: 10.1016/j.tcm.2017.05.003. Epub 2017 May 10. PubMed 28619579 ↗
  • Uradu A, Wan J, Doytchinova A, Wright KC, Lin AYT, Chen LS, Shen C, Lin SF, Everett TH 4th, Chen PS. Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation. Heart Rhythm. 2017 Jul;14(7):964-971. doi: 10.1016/j.hrthm.2017.03.030. Epub 2017 Mar 24. PubMed 28347833 ↗
  • Doytchinova A, Hassel JL, Yuan Y, Lin H, Yin D, Adams D, Straka S, Wright K, Smith K, Wagner D, Shen C, Salanova V, Meshberger C, Chen LS, Kincaid JC, Coffey AC, Wu G, Li Y, Kovacs RJ, Everett TH 4th, Victor R, Cha YM, Lin SF, Chen PS. Simultaneous noninvasive recording of skin sympathetic nerve activity and electrocardiogram. Heart Rhythm. 2017 Jan;14(1):25-33. doi: 10.1016/j.hrthm.2016.09.019. Epub 2016 Sep 23. PubMed 27670627 ↗
  • Tang CL, Tsai WC, Lee JY, Wang YK, Chen YH, Liu YW, Lin MC, Fang PT, Huang YL, Wu IC. Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes. BMC Cancer. 2022 Oct 22;22(1):1086. doi: 10.1186/s12885-022-10180-8. PubMed 36271384 ↗
  • Huang TC, Lin SJ, Chen CJ, Jhuo SJ, Chang CW, Lin SC, Chi NY, Chou LF, Tai LH, Liu YH, Lin TH, Liao WS, Kao PH, Cheng MC, Hsu PC, Lee CS, Lin YH, Lee HC, Lu YH, Yen HW, Lin TH, Su HM, Lai WT, Dai CY, Lee CH, Chen PS, Lin SF, Tsai WC. Skin sympathetic nerve activity and ventricular arrhythmias in acute coronary syndrome. Heart Rhythm. 2022 Oct;19(10):1613-1619. doi: 10.1016/j.hrthm.2022.04.031. Epub 2022 May 5. PubMed 35525422 ↗

Individual participant data

Plan to share: Undecided

08

Registry details

Key details

Study ID
NCT03243448
Lead sponsor
Kaohsiung Medical University Chung-Ho Memorial Hospital
Responsible party
Sponsor
First posted
Aug 9, 2017
Start date
Aug 1, 2016
Primary completion
Jul 31, 2030 (estimated)
Completion
Jul 31, 2032 (estimated)
Last update
Aug 10, 2026
View the source record on ClinicalTrials.gov ↗

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