An interventional study of Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement and Open flap debridement in Periodontitis, sponsored by Hadeer Ashraf Hassan Roushdy. Status unknown. Per ClinicalTrials.gov, last updated 2019-01-17.
Sponsored by Hadeer Ashraf Hassan Roushdy · Not applicable, Interventional, and Treatment
this study is to evaluate the use of advanced platelet rich fibrin (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) versus open flap debridement alone in the management of mandibular molar grade II defects.
In the management of mandibular molar grade II furcation defects, no difference exists in gain of horizontal clinical attachment level between the use of advanced platelet rich fibrin (A-PRF) + with nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) and open flap debridement (OPD) alone .
Patient-related criteria:
Teeth related criteria:
Exclusion Criteria:
Patient-related criteria:
Teeth related criteria:
Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OFD).
Procedure: Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement
Open flap debridement alone.
Procedure: Open flap debridement
will treated with OFD +A- PRF+ nano-crystalline hydroxyapatite bone substitute,10 mL of blood will be drawn from only patient assigned to the intervention group by vein puncture of the antecubital vein and is collected in sterile glass test tube, without any anticoagulant. * The blood will be quickly collected, and the tube will immediately centrifuge at 1500 rpm for14 min at room temperature. * After centrifugation, the A-PRF clot will be removed from the tube using sterile tweezers and placed on sterile woven gauze. Membrane will prepared by compressing clots between two pieces of woven gauze.
a periodontal access flap will be initiated by intrasulcular incisions on the buccal and lingual aspects. The incisions will be carried as far interproximally as possible to preserve the entire Interdental papillae and to achieve primary wound closure.
Relative Vertical Clinical Attachment Level (RVCAL)
relative vertical clinical attachment level (RVCAL) along with gingival marginal level (GML) will be measured from the apical level of customized acrylic stents with grooves to ensure a reproducible placement of a periodontal probe
Time frame: 6 months
Relative Horizontal Clinical Attachment Level (PHCAL)
relative vertical clinical attachment level (RVCAL) along with gingival marginal level (GML) will be measured from the apical level of customized acrylic stents with grooves to ensure a reproducible placement of a periodontal probe
Time frame: 6 months
Probing Depth (PD)
Probing depth measured from the gingival margin to the base of the pocket.
Time frame: 6 months
Gingival margin Level (GML)
• Williams graduated probe will be used for vertical measurement and gingival margin level and Nabers probe for horizontal measurements.
Time frame: 6 months
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is status unknown, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.
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