A Phase 2 interventional study of acetominophen, ibuprofen, oxycodone and Oxycodone in Hernia, Abdominal and Pain, sponsored by Khashayar Vaziri. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-08-04.
Sponsored by Khashayar Vaziri · Phase 2, Interventional, and Treatment
Investigating the effect of multimodal pain treatment after hernia repair
This is a randomized, non-blinded study comparing the effects of multimodal pain management (ibuprofen, tylenol, and narcotics/oxycodone as needed) for relief of post-operative pain in patients who undergo hernia repair. Patients who present for elective hernia surgery will be randomized in a 1:1 fashion by pre-operative pain score into a multimodal pain treatment group or conventional opiod treatment group for post-operative pain management. They will be followed up after their surgery to evaluate their pain scores and narcotic use.
82 studies on the registry are indexed under Hernia, Abdominal; 19 are open to participants now.
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Patients will receive scheduled ibuprofen 400mg po q 4 hours and acetominophen 1gram po q 8 hours during the post operative phase and oxycodone 5mg po q 4 to 6 hours as needed for pain control.
Drug: acetominophen, ibuprofen, oxycodone
Patients will receive oxycodone 5mg po q 4 to 6 hours as needed during their post operative phase for pain control.
Drug: Oxycodone
Drug pages: Acetaminophen · Ibuprofen · Oxycodone
Multimodal pain treatment group
Also known as: Tylenol, Advil, OxyContin
Classic opiod pain treatment group
Also known as: OxyContin
Post operative pain scores at rest and during movement
Patients will be called on post operative days 1-3 and asked to rate their pain while at rest and during movement using the following scales: On a scale of 1-10, with 1=no pain and 10= the worst pain, what has been your average pain level since surgery during REST? 1 2 3 4 5 6 7 8 9 10 On a scale of 1-10, with 1=no pain and 10= the worst pain, what has been your average pain level since surgery during MOVEMENT (such as walking across the room)? 1 2 3 4 5 6 7 8 9 10 Patients will also be asked the same two pain scales (pain at rest and during movement) at the first post-operative appointment, which will occur within 14 days of their surgery. The scores for pain at rest and during movement will not be summed or averaged together, so that the maximum score on each scale is 10 (worst pain), and the minimum score is 1 (no pain). Scores will not be summed across days. Lower scores are considered a better outcome, and higher scores are considered a worse outcome.
Time frame: 1-14 days after surgery
Narcotic use
Amount of oxycodone pills taken
Time frame: 1-14 days after surgery
Plan to share: No
This study is withdrawn, as verified in Jul 2021. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Acetaminophen · Ibuprofen · Oxycodone