An observational study in Primary Aldosteronism and Stroke, sponsored by Changi General Hospital. Completed at 1 site in Singapore. Open to participants aged 21 Years to 80 Years. Per ClinicalTrials.gov, last updated 2022-05-20.
Sponsored by Changi General Hospital · Observational
Strokes leads to significant morbidity and mortality, and hypertension is the most important risk factor for strokes. It is estimated that up to 10% of patients with hypertension have the underlying, treatable condition of primary aldosteronism. Hence, we hypothesize that the prevalence of primary aldosteronism is high in patients with strokes, a complication of long-standing hypertension.
Patients admitted with an acute stroke to the Acute Stroke Unit, Changi General Hospital, will be screened for Primary Aldosteronism three months post-stroke, and confirmatory tests will be done with saline-infusion test.
7,287 studies on the registry are indexed under Stroke; 2,006 are open to participants now.
This study's enrollment of 300 is above the median of 160 across 1,692 observational studies indexed under Stroke.
Browse Stroke studies →Changi General Hospital is the lead sponsor of 98 studies on the registry; 18 are open to participants now.
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Prospective study to evaluate the prevalence of primary aldosteronism in patients with an acute stroke. 300 patients admitted with CVA/TIA will be enrolled into the study.
Exclusion Criteria:
a. Pregnant patients
All patients admitted to the Acute Stroke Unit
Diagnostic Test: Aldosterone renin ratio
Aldosterone Renin Ratio to screen for Primary Aldosteronism
Percentage of patients with stroke with confirmed primary aldosteronism in patients admitted to the acute stroke unit for stroke
Percentage of patients with confirmed Primary Aldosteronism using confirmatory test
Time frame: 6 months
Accuracy of Screening test in early period post-stroke
To determine if the screening blood test for primary aldosteronism performed within 1 week post-stroke is equally accurate compared to being performed 2-4 months post-stroke.
Time frame: 3 months
Percentage of unilateral primary aldosteronism in patients admitted with acute stroke
Percentage of unilateral PA amongst patients with stroke
Time frame: 6 months
Percentage of patients with positive screening test in patients admitted with acute stroke
Time frame: 3 months
Blood pressure change after treatment for primary aldosteronism
Time frame: 12 months
Cardiac Complications
Cardiac complications in patients with primary aldosteronism, compared to those without primary aldosteronism, as assessed by transthoracic echocardiography features of left ventricular hypertrophy / mass, and diastolic dysfunction
Time frame: 6 months
Plan to share: No
This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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Changi General Hospital