An interventional study of Thyroxine in Sub Clinical Hypothyroidism and Pregnancy Loss, sponsored by Hawler Medical University. Completed. Open to female participants aged 18 Years to 42 Years. Per ClinicalTrials.gov, last updated 2018-10-29.
Sponsored by Hawler Medical University · Not applicable, Interventional, and Screening
Subclinical hypothyroidism(SCH) is the elevated thyroid stimulating hormone (TSH) with normal free Thyroxine levels and it is a mild or compensated form of primary hypothyroidism. It has been suggested that SCH is more prevalent in infertile women (especially in women with ovulatory disorders.Various rates of SCH was reported in infertile women in different populations
Despite well-established recommendations on screening and treatment of overt hypothyroid in infertile women, there is a controversy regard the treatment of SCH in infertile women .
There are few published data on the prevalence of SCH and the outcome of treatment of SCH in infertile women, many were conducted during IVF cycles . Moreover there are inconsistent results in these studies being authors advised to treat SCH before IVF and some other articles find out no any benefit regarding treatment with Thyroxine in SCH
247 studies on the registry are indexed under Hypothyroidism; 57 are open to participants now.
This study's enrollment of 168 is above the median of 78 across 128 interventional studies indexed under Hypothyroidism.
Browse Hypothyroidism studies →Hawler Medical University is the lead sponsor of 56 studies on the registry; 6 are open to participants now.
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Levothyroxine sodium(Euthyrox 50µg and 25 µg MerckSerono) treatment was initiated and the women were followed in a combined clinic of endocrinologist and Gynecologist. 2.5 µg of Thyroxine daily was prescribed to women with TSH more than 2.5 mIU/L. Women with TSH more than 4mIU/L were given 50 µg daily . When pregnancy was confirmed Thyroxine was continued till 13 weeks gestation .
Drug: Thyroxine
Thyroxine was prescribed with the diagnosis of SCH and continued when pregnancy was confirmed
Also known as: Euthyrox
Pregnancy
Pregnancy was confirmed using human chorionic gonadotropin hormone (hCG) estimation from blood
Time frame: 2 years
Miscarriage rate
viability and growth of embryos were confirmed by ultrasound
Time frame: 13 weeks
No study locations are listed for this record.
Plan to share: No — Data of the research can be applied on request
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.
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Hawler Medical University