An observational study in Mild Cognitive Impairment, Alzheimer Disease and Dementia, Vascular, sponsored by Shanghai Mental Health Center. Status unknown at 1 site in China. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-01-10.
Sponsored by Shanghai Mental Health Center · Observational
Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts. To address this important public health problem, cohort study on elderly cognitive disorders should be carry out. The methods of early prevention, early diagnosis and early treatment the cognitive disorders in elderly should be found to reduce the burden of the social and economic issue due to dementia. At present, the international corresponding guidelines have taken gene and brain imaging biomarkers as important indicators of dementia pathogenesis research, accurate diagnosis and targeted intervention. Based on the above understanding, the study carry out the population cohort study based on accurate diagnosis and construct the high standard information and sample bank. The study will establish the standard and quality system of geriatric cognitive disorders cohort study (unified standards and norms). The study will integrate the standard biological samples stratified acquisition function module (homogeneity and precision) of elderly cognitive disorders, and complete the construction of biological samples bank and clinical diagnosis and treatment information database. The study will apply and develop brain structural and pathological imaging technology to support precision diagnosis of senile cognitive disorders. The study will evaluate whether peripheral nerve degeneration can predict central nervous system degeneration based on the large cohort of elderly study. In addition, The study will make an effective supplement the sample bank construction of Shanghai Mental Health Center.
The neuropsychological test battery are used to access the cognitive function of subjects in the study. The brain MRI and biochemical examination will be done in the screening period. The samples such as plasma, serum, urine and faeces et al. of the subjects will be collected in the study.
3,678 studies on the registry are indexed under Alzheimer Disease; 872 are open to participants now.
This study's planned enrollment of 10,000 is above the median of 200 across 751 observational studies indexed under Alzheimer Disease.
Browse Alzheimer Disease studies →Shanghai Mental Health Center is the lead sponsor of 267 studies on the registry; 93 are open to participants now.
Counted across the registry records on this site, refreshed daily.
10,000 adult Chinese aged 60 and up who have been living Shanghai will be recruited.
Exclusion Criteria:
Dementias
Other: Naturalistic observation
Normal Aging with normal cognitive function
Other: Naturalistic observation
Naturalistic observation
Also known as: Normal Aging
Prevalence, incidence of neurocognitive disorder
Prevalence, incidence of neurocognitive disorder such as AD, MCI and other types of dementia
Time frame: 5 years
Prevalence, incidence of mood disorder
Prevalence, incidence of mood disorder such as depression, anxiaty
Time frame: 5 years
conversion rate
conversion rate of neurocognitive disorder from Normal Elderly
Time frame: 5 years
This study is status unknown, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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Shanghai Mental Health Center